Topic
Diodone
About: Diodone is a research topic. Over the lifetime, 36 publications have been published within this topic receiving 543 citations. The topic is also known as: Iodopyracet & pelvirinic acid.
Papers
Journal Article•
TL;DR: The results suggest that more than 90 per cent of the conventional drainage was carried by pores xoith an apparent diameter of more than 0.16 n.centration after 1 minute, while throughout the experiments the diodone concentration in the effluent remained lower than expected from, a bulk flow through well-defined channels.
Abstract: centration after 1 minute, while throughout the experiments the diodone concentration in the effluent remained lower than expected from, a bulk flow through well-defined channels. The low concentration was due to a rapid diffusion of diodone into the tissues of the limbus region. The labeled albumin entered the uvea and the sclera in such amounts as to indicate that about 20 per cent of the labeled fluid had passed out by way of unconventional uveoscleral routes. The results suggest that more than 90 per cent of the conventional drainage was carried by pores xoith an apparent diameter of more than 0.16 n. t has been demonstrated in many ways that in the primate eye aqueous humor flows from the anterior chamber into Schlemm's canal. It is quite clear that the aqueous first passes into the spaces of the trabecular meshwork but how it then passes through the inner wall of Schlemm's canal is a matter of question. Much physiologic evidence 1 " 4 suggests that the flow occurs
138 citations
Journal Article•
TL;DR: The anterior chamber fluid in cynomolgus monkeys was replaced by a solution of albumin and diodone (iodopyracet) labeled with different isotopes of iodine and it was concluded that diod one leaves the anterior chamber both by flow and diffusion but that the proteins leave the posterior chamber essentially by bulk flow.
Abstract: The anterior chamber fluid in cynomolgus monkeys was replaced by a solution of albumin and diodone (iodopyracet) labeled with different isotopes of iodine. After 45 to 120 minutes the chamber fluid was collected and analyzed. The same type of experiment icas performed with albumin and my o glob in and with albumin and gamma globulin. In some of the experiments with albumin and myoglobin, the tissues of the eyes were also analyzed. The turnover rate constant for albumin in the anterior chamber was 0.021 minute- 1 at a mean intraocular pressure of 13.8 mm. tig. The turnover rate constants for diodone, myoglobin, and gamma globulin, in the same order, were 1.31, 1.023, and 0.997 times that for albumin. In five 90 minute experiments, on an average, 25 per cent (range 12 to 36 per cent) of the labeled albumin that had left the anterior chamber was present in the intraocular tissues and the tissues fust outside the eye. For myoglobin the corresponding mean figure was 16 per cent. It is concluded that diodone leaves the anterior chamber both by flow and diffusion but that the proteins leave the anterior chamber essentially by bulk flow. Part of this takes place by way of unconventional routes through the anterior uvea, the suprachoroid, and the solera. The total volume of the anterior and posterior chambers was on an average 123 id and the rate of flow of aqueous humor into the anterior chamber was about 1 to 2 id per minute.
94 citations
48 citations
36 citations
TL;DR: The choice of medium for pyelography, cardiography, and angiography is discussed: in each case it is shown that diodone is the most suitable medium.
Abstract: A comparison is made of some properties of diodone (Per-Abrodil), iodoxyl (Uroselectan B), sodium iodohippurate (Hippuran) and four other iodine-containing organic substances. Their actions on the heart, the blood vessels and the blood pressure are described. By a special method, their effects on intra-carotid injection, as in cerebral angiography, have been investigated in cats. One of the substances, which had not previously been used and which showed promise as a new contrast medium, was found to be badly tolerated by human subjects. The choice of medium for pyelography, cardiography, and angiography is discussed: in each case it is shown that diodone is the most suitable medium. It is also shown that diodone is worthy of clinical trial for cerebral angiography.
28 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 1987 | 1 |
| 1978 | 2 |
| 1977 | 3 |
| 1976 | 1 |
| 1968 | 1 |
| 1967 | 1 |