Topic
Dimethisterone
About: Dimethisterone is a research topic. Over the lifetime, 63 publications have been published within this topic receiving 1666 citations. The topic is also known as: Dimethisterone anhydrous.
Papers published on a yearly basis
Papers
TL;DR: It is suggested that development of neoplasia in the endometrium can be extremely sensitive to hormonal factors: if an oral contraceptive, like Oracon, emphasizes the estrogenic component, promotio...
Abstract: Female residents of King and Pierce Counties in the state of Washington in whom endometrial cancer was diagnosed during 1975–77 were interviewed concerning prior use of oral contraceptives. Their responses were compared with those of a random sample of women from the same population. Women who had taken Oracon (0.1 mg of ethinyl estradiol and 25 mg of dimethisterone) were estimated to have a risk of endometrial cancer 7.3 times that of other women (P = 0.007). This elevation in risk was not seen in users of other sequential preparations. Women who had used combined oral contraceptives had only 50 per cent of the incidence of endometrial cancer of nonusers (P = 0.05), although the protective effect was not evident among those who subsequently took menopausal estrogens for more than two years. These associations suggest that development of neoplasia in the endometrium can be extremely sensitive to hormonal factors: if an oral contraceptive, like Oracon, emphasizes the estrogenic component, promotio...
193 citations
Journal Article•
TL;DR: This report is a summary of the first 21 cases entered in the Registry of endometrial carcinoma in young women who were taking oral contraceptives, all of these patients were less than 40-years-old.
124 citations
TL;DR: There were, however, notably higher incidences of nulliparity, obesity, and sclerocystic ovaries—all features traditionally associated with endometrial carcinoma—in the patients not receiving oral contraceptives or receiving combined agents, suggesting that the group receiving sequentials may not represent the same constitutionally predisposed population.
Abstract: Women under 40 years of age rarely develop carcinoma of the endometrium, this age group comprising less than 3% of all cases in most large series. The Registry for Endometrial Carcinoma in Young Women Taking Oral Contraceptive Agents has recorded and studied 30 cases in women under 40 with a history of oral contraceptive administration, and these are compared with 25 cases in the same age group which were accessioned at the Armed Forces Institute of Pathology prior to the era during which these agents have been available, and with series reported in the literature totaling 137 cases with no contraceptive history. In the first group, special attention is paid to the 20 women who received sequential agents exclusively or predominantly, since the association with these agents (primarily Oracon) is much higher than would be expected from the fact that less that 10% of oral contraceptives used in this country are of the sequential type. An analysis of the three groups reveals a similar incidence of the various histologic types (primarily well differentiated tumors with a relatively favorable prognosis), the only difference being the presence of secretory features in 14 of 29 oral contraceptive users vs. only two of 25 women not taking these agents. Clinical and pathologic staging were also predominantly favorable, and comparable in all groups. There were, however, notably higher incidences of nulliparity, obesity, and sclerocystic ovaries--all features traditionally associated with endometrial carcinoma--in the patients not receiving oral contraceptives or receiving combined agents, suggesting that the group receiving sequentials may not represent the same constitutionally predisposed population. Only three of 55 women among our personally reviewed cases have thus far died of cancer (one in the contraceptive group and two in the non-user group) and all three of these had poorly differentiated tumors with myometrial invasion. The excellent prognosis for most patients in this age group is thus confirmed.
92 citations
TL;DR: A study is now in progress to determine whether long-term use of Oracon produces premalignant changes in the endometrium, which has been implicated in the development of vaginal adenocarcinoma in female offspring of women treated during pregnancy with it.
73 citations
TL;DR: Hormone formulation and estrogen/progestin potency were evaluated in relation to triglyceride and cholesterol concentrations in total plasma and lipoprotein fractions and in relationto lipid composition among a random sample of female telephone company personnel.
56 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2011 | 1 |
| 1984 | 1 |
| 1983 | 1 |
| 1982 | 2 |
| 1980 | 4 |
| 1977 | 4 |