Abstract: Apparatuses for use in whole-body hypothermia include a high-flow hyperthermia circuit coupled to a low-flow dialysis circuit in a manner which reduces tensioning of membranes in the dialyzer (152) of the dialysis circuit. The arrangement thereby allows proper membrane movement to assist in mixing a sorbent suspension (176) circulated on the sorbent side of the dialyzer. Additional dialysis apparatuses include advantageous disposable packs (300) including the dialyzer (152), sorbent heat exchangers (186) arranged to cooperate with heating elements on base units of the apparatuses, and adaptations for very high flow rates useful in the hyperthermic treatment of cancers.

Abstract: Method and device for determining in dialysis treatment the content of waste products in the outgoing dialysis liquid from the dialyzer. Measurement of the concentration of a certain substance or a combination of substances included in the waste products is effected spectrophotometrically directly on the outgoing dialysis liquid from the dialyzer. For that purpose there is provided after the dialyzer in or after the dialysing machine a measuring cell for spectrophotometric measurement. The measurement value obtained is multiplied by the flow of dialysis liquid for determining the content of said substance or said combination of substances in the outgoing dialysis liquid from the dialyzer.

Abstract: A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, an RO water pressurizing line 5, an RO water pressurizing pump 51 provided in the RO water pressurizing line 5, an artery side blood line 6, a blood pump 61 provided at the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing RO water into a communication line of the used dialysate, dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.

Abstract: A hemodialyzer apparatus comprises a reusable dialyzer membrane as well as reusable blood flow path and dialysis flow path units. The apparatus automatically primes itself and makes dialysis solution from dry chemicals, concentrates, and fresh water which is provided to the apparatus. Also, after use, the apparatus automatically prepares cleaning and rinsing solution for the cleaning and rinsing of the dialyzer membrane as well as the dialyzate and blood flow path means, to provide a system which is so simplified in terms of automatic operation that it may be usable for daily dialysis at home.

Abstract: This invention provides a dialysis-access graft fistula having self-sealing ports for use in hemodialysis. The self-sealing ports can be repeatedly used for the cannulation required for the blood flows associated with hemodialysis. The ports self-seal after each puncture.

Abstract: Acid concentrates, and dialysate compositions prepared therefrom, contain citric acid and an effective amount of a buffering agent selected from acetate and/or lactate. The buffering agent allows a physiologically acceptable amount of citrate to maintain the desired pH of the dialysate.

Abstract: A procedure combining diphasic dialysis extraction with in situ acylation and gas chromatography/mass spectrometry (GC/MS) determination was developed for detection and quantification of the mycotoxin patulin in apple juice. Apple juice samples spiked with 4-N,N-dimethylaminopyridine were dialyzed using methane chloride and acetic anhydride inside dialysis tubing. Patulin was derivatized into its acetate and collected in the tubing after diphasic dialysis and was directly determined using GC/MS with the selective ion monitoring mode without further concentration and cleanup steps. Quantification was carried out by a calibration curve with an internal standard of correlation. The appropriate parameters of both dialysis and derivatization were examined. The linear range of the calibration curve was found to be 10−250 μg/L for patulin, and the limit of quantification was 10 μg/L. Levels of patulin ranging from 0 to 107.2 μg/L with 77−109% recovery were found in 10 apple samples. The technique combining dipha...

Abstract: ObjectiveTo compare the biochemical and nutritional effects of amino acid dialysis with dextrose dialysis in children receiving continuous cycling peritoneal dialysis (CCPD).DesignA prospective ran...

Abstract: A connector for use in peritoneal dialysis, includes a base body having a first tube for attachment of a container for dialysis solution, and a second tube for attachment of a peritoneal catheter. Positioned in a passageway between the first tube and the second tube is a closure piece which so interacts with an actuator that an operation of the actuator causes the closure piece to move in a linear direction from a first position into a second position in which the fluid flow between the first tube and the second tube is closed while the first tube is sealed off.

Abstract: Dialysis system comprising: a source (30) of dialysis solution; a dialyzer (38) having a semipermeable membrane delimiting a first chamber through which blood circulates and a second chamber through the circulating dialysis solution, the second chamber being connected such to said source (30) dissolution dialysis through a via (32) input dialysis solution and said second chamber also being connected to a means (42) output dialysis solution, a track (76) of arterial blood and a means (64) venous blood connected to an inlet and outlet of said first chamber of the dialyzer (38) respectively, means (66) for placing said satellite (76) of arterial blood and said channel (64) venous blood in a first orientation, wherein said via blood carries blood from an upstream portion of the fistula of a patient and said venous line carries blood toward a downstream portion of said fistula and for reconfiguration said arterial and venous lines to a second or G uidance, wherein said arterial line carries blood from a downstream portion of said fistula and said venous line carries blood toward an upstream portion of said fistula; means (46, 106) to determine a first value for the concentration of a solute in said channel (42) output dialysis solution for dialysis conditions in which said arterial and venous lines are in said first orientation means (46 , 106) to determine a second value for the concentration of said solute in said channel (42) output dialysis solution for dialysis conditions in which said arterial and venous lines are in said second orientation, and means (200) for calculating from said first and second values, a hemodialysis parameter.

Abstract: A container has a single primary chamber linked to a single secondary chamber via a common wall in which has been fused a semi-permeable membrane. A lid for the primary chamber enables sealing of a sample (not shown) inserted into the primary chamber, sealingly enclosing any dangerous fraction of the sample, which fraction and the lid closed any infectious material hermetically sealed in as this cannot cross the semi-permeable membrane, due to the latter being provided with a cut-off matched to the molecular size of the type of sample with which the container is to be used. However, material of a lower molecular weight than the dangerous fraction can move across the membrane in either directions by dialysis or osmosis.

Abstract: ObjectiveThe purpose of the study was to test a novel approach to monitoring the adherence of continuous ambulatory peritoneal dialysis (CAPD) patients to their dialysis prescription.DesignA descri...

Abstract: An arterial needle removes blood from the access to an extracorporeal circuit comprising a dialyzer and a venous needle returns the blood to the access site. Blood passes along one side of the membrane of the dialyzer and dialysis fluid along the other side. Fistula or access recirculation is detected by changing the blood flow rate, monitoring the concentration of a substance in the dialysate emitted from the dialyzer and correlating a change in the concentration to the change of the blood flow rate.

Abstract: A selected parameter of a dialysis liquid is monitored by determining the propagation velocity of ultrasonic pulses transmitted through the liquid An Independent claim is also included for dialysis liquid preparation equipment including a dialysis liquid parameter monitoring system which receives (28) the dialysis liquid, transmits (29, 30) ultrasonic pulses through the liquid, receives (29, 30) the ultrasonic pulses and determines (35) the ultrasonic pulse propagation velocity through the liquid and thus the selected parameter

Abstract: For monitoring a vascular access during a dialysis treatment, the pressure in both the arterial and the venous branch (5, 7) of the extracorporeal blood circuit by means of pressure sensors (18, 19) is monitored. Characteristic values (W

Abstract: A process for removing toxins from blood is disclosed. The process involves contacting the blood with a microporous ion exchanger to remove toxins in the blood. Alternatively, the blood can be contacted with a dialysis solution which is then contacted with the ion exchanger. The microporous ion exchangers are represented by the following empirical formulae: A.sub.p M.sub.x Zr.sub.1-x Si.sub.n Ge.sub.y O.sub.m (I) and A.sub.p M.sub.x Ti.sub.1-x Si.sub.n Ge.sub.y O.sub.m (II)

Abstract: The concept of the feeding strategy was to minimise the formation of inhibiting metabolites and to increase the yield of monoclonal antibodies in fed-batch cultures of hybridoma cells by a balanced supply of substrates. A process control system based on fieldbus technology was used for monitoring and control. External program routines were implemented to control dissolved oxygen (DO) and to calculate the oxygen uptake rate (OUR) and cumulative oxygen consumption (COC) simultaneously. A concentrated feed solution was supplied according to the off-line estimated stoichiometric ratio between oxygen and glucose consumption (GC). Feeding was initiated automatically when the OUR decreased due to substrate limitation. The antibody concentration increased three-fold compared to the conventional batch culture by applying this strategy. But it was not possible to avoid inhibition by ammonia during the fed-batch phase. This was accomplished by the use of a dialysis membrane. Dialysis fed-batch cultures were performed in a membrane dialysis reactor with a `nutrient-split' feeding strategy, where concentrated medium is fed to the cells and toxic metabolites are removed into a buffer solution. This resulted in a ten-fold increase of the antibody concentration compared to the batch. Amino acid concentrations were analysed to identify limiting conditions during the cultivation and to analyse the performance of the nutrient supply in the fed-batch and dialysis fed-batch.

Abstract: Pathophysiology of the oxidative stress and its implication in uremia and dialysis vitamin E as an antioxidant agent chronic haemolysis and erythrocyte survival in haemodialysis patients treated with vitamin E-modified dialysis filters development of vitamin E-modified membrane evaluation of excebrane by infrared imaging hydraulic and flow dynamic characteristics of vitamin E-bonded dialyzers urea clearance and ionic dialysance of excebrane haemodialyzers effect of several cellulosic dialytic membranes on hyperhomocysteinemia and on the oxidative stress in dialysis patients - any role for curay and vitamin E? hollow-fiber dialyzer employing vitamin E-bonded membrane - a morphological analysis does vitamin E bound on dialysis membrane improve the LDL susceptibility to oxidation? lessons from an in vitro model effect of vitamin E conjugated to dialysis membranes on immunohaematopoietic cell growth and signalling effects of vitamin E-modified dialyzer (Excebrane) on beta-2-microglobulin structure and removal lipid peroxidation, leukocyte function and apoptosis in haemodialysis patients treated with vitamin E-modified filters morphologic evaluation of red blood cells using vitamin E-modified dialysis filters Excebrane - haemocompatibility studies by the intradialytic monitoring of oxygen saturation effect of a new vitamin E-coated membrane on glycoxidation during haemodialysis in vivo evaluation of biocompatibility of a new dialyzer employing the vitamin E-modified cellulose membrane "Excebrane E" - study of mechanisms involved in mononuclear cell activation increased red blood cell survival reduces the need of erythropoietin in haemodialyzed patients treated with exogenous glutathione and vitamin E-modified membrane a chemiluminescence assay for the detection of reactive oxygen species produced by human neutrophils - in vitro comparison of vitamin E-modified multilayer haemodialysis filter with a polysulfone dialyzer immunological biocompatibility characterization of a vitamin E-bonded membrane long-term effects of vitamin E-bonded dialysis membrane on mononuclear cell activation, malondialdehyde generation and endothelial function in ESRD patients effect of vitamin E-modified regenerative cellulose membrane on neutrophil superoxide anion radical production and lipid peroxidation suppressive effects of vitamin E-coated dialysis membrane on haemodialysis-induced neutrophil activation.

Abstract: Bei einer Vorrichtung zur Dialysebehandlung mit einem extrakorporalen Blutkreislauf, in den die Blutkammer (3) einer durch eine semipermeable Membran (2) in die Blutkammer und eine Dialysierflussigkeitskammer (4) unterteilten Dialysators (1) geschaltet ist, wird zur Einstellung eines verringerten Dialysierflussigkeitsflusses durch die Dialysierflussigkeitskammer ein Teil der Dialysierflussigkeit uber eine Bypassleitung (14) umgeleitet. Is connected in a device for dialysis treatment with an extracorporeal blood circuit, in which the blood chamber (3) a through a semipermeable membrane (2) into the blood chamber and a dialysis (4) divided dialyzer (1), is used to set a reduced dialysing fluid flow through the dialyzing fluid part of the dialysis fluid diverted via a bypass line (14). Da bei verringertem Dialysierflussigkeitsflus die Konzentration einer Substanz im Dialysierflussigkeitsweg im wesentlichen die Konzentration der selben im Blutkreislauf annimmt, konnen hamodynamische Parameter allein aus Messungen auf der Dialysierflussigkeitsseite bestimmt werden. Since at reduced dialysis solution, the concentration of a substance in the dialysis fluid takes the concentration of the same in the bloodstream essentially hemodynamic parameters can be determined solely from measurements on the dialysate side. Wenn die Dialysierflussigkeit uber die Bypassleitung umgeleitet wird, ergeben sich keine Probleme bei der Temperaturregelung. When the dialysis fluid is diverted through the bypass line, there are no problems with the temperature control result. Auch die Zusammensetzung und die Homogenitat der Dialysierflussigkeit entspricht genau den Verhaltnissen wahrend der Dialysebehandlung. Also the composition and the homogeneity of the dialysis fluid corresponding exactly to the ratios during the dialysis treatment.