Topic
DHRS1
About: DHRS1 is a research topic. Over the lifetime, 2 publications have been published within this topic receiving 11 citations. The topic is also known as: SDR19C1 & dehydrogenase/reductase (SDR family) member 1.
Papers
TL;DR: By large-scale sequencing analysis of a human fetal brain cDNA library, a novel human SDR-type dehydrogenase/reductase gene named DHRS1 is isolated, encoding a 314-amino-acid polypeptide which has a SDR motif.
Abstract: Short-chain dehydrogenases/reductases (SDR) constitute a large protein family of NAD(P)(H)-dependent oxidoreductase. They are defined by distinct, common sequence motifs and show a wide range of substrate specialisms. By large-scale sequencing analysis of a human fetal brain cDNA library, we isolated a novel human SDR-type dehydrogenase/reductase gene named Dehydrogenase/reductase (SDR family) member 1 (DHRS1). The DHRS1 cDNA is 1411 base pair in length, encoding a 314-amino-acid polypeptide which has a SDR motif. Northern blot reveals two bands, of about 0.9 and 1.4 kb in size. These two forms are expressed in many tissues. The DHRS1 gene is localized on chromosome 14q21.3. It has 9 exons and spans 9.2 kb of the genomic DNA.
7 citations
TL;DR: Based on in silico and experimental approaches, DHRS1 is described as a likely monotopic protein that interacts with the membrane of the endoplasmic reticulum that fit to a role in steroid and/or xenobiotic metabolism.
Performance Metrics
| Year | Papers |
|---|---|
| 2019 | 1 |
| 2001 | 1 |