Topic
Dextrorotatory
About: Dextrorotatory is a research topic. Over the lifetime, 176 publications have been published within this topic receiving 1253 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: The present results support the contention that binding to the [3H]PCP labeled recognition site may reside in either the levorotatory or the dextrorotatory enantiomer and suggest that certain dextRORotatory morphinan derivatives may prove to be useful probes in further investigations of the molecular characteristics of the [ 3H] PCP binding site in brain membrane preparations.
76 citations
Patent•
TL;DR: Dextrorotatory isomer of 6-(5-chloro-2pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, its preparation and pharmaceutical compositions containing it which are usable as tranquillisers and hypnotics.
Abstract: Dextrorotatory isomer of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, its preparation and pharmaceutical compositions containing it which are usable as tranquillisers and hypnotics.
49 citations
TL;DR: In this paper, maleic anhydride and l-α-methylbenzyl vinyl ether were copolymerized by a free radical mechanism in homogeneous solution to yield a levorotatory copolymers.
Abstract: Maleic anhydride and l-α-methylbenzyl vinyl ether were copolymerized by a free radical mechanism in homogeneous solution to yield a levorotatory copolymer. Upon removal of the original asymmetric center by photobromination and hydrolysis, a dextrorotatory copolymer was produced. This reversal of the sign of rotation can be attributed only to an excess of one configuration in the chain backbone induced during the propagation step of the polymerization.
48 citations
TL;DR: The North Indian vetiver variety has yielded a new laevo-rotatory crystalline sesquiterpene alcohol, which is named as laevojunenol as discussed by the authors.
39 citations
TL;DR: This work has found that the dextrorotatory, more potent, enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole has the (1S,2S) absolute configuration of GT-2331.
Abstract: GT-2331 is a potent histamine H(3) antagonist which has entered clinical trials. Efficient multigram syntheses of this compound and its enantiomer are described. The literature reports that GT-2331 is the dextrorotatory (+), more potent, enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole with the absolute configuration of (1R,2R)-1. However, we found that the dextrorotatory, more potent, enantiomer of 4-[2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole has the (1S,2S) absolute configuration. We suggest a reconsideration of the absolute configuration of GT-2331.
37 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 2 |
| 2019 | 8 |
| 2018 | 4 |
| 2017 | 1 |
| 2016 | 1 |
| 2015 | 2 |