Topic
Dextromethadone
About: Dextromethadone is a research topic. Over the lifetime, 3 publications have been published within this topic receiving 39 citations.
Papers
TL;DR: There appears to be no advantage in levomethadone over racemic methadone in the treatment of patients in maintenance programs, and analysis of 25 variables showed no significant differences between levo‐ and racemic methamphetamine.
Abstract: Sixty-six patients participated in a double-blind, crossover study comparing side effects, drug use, clinic attendance, and dose changes on levomethadone and d,l (racemic) methadone. The hypothesis under examination was that dextromethadone, while adding no narcotic actions to the racemate, was contributing to side effects. An earlier single-blind pilot study showed that 9 out of 11 side effects improved while patients were receiving levomethadone, but this larger study did not duplicate those results. Analysis of 25 variables showed no significant between levo- and racemic methadone. There appears to be no advantage in levomethadone over racemic methadone in the treatment of patients in maintenance programs.
41 citations
Journal Article•
4 citations
TL;DR: In this article, the authors bring the experience of an Italian Addiction Centre back to the use of this new formulation in the real life, analyzing the efficacy, the trend of adverse events and pharmacological iterations in a context in which the treated population often uses besides the opiates, cocaine and alcohol, are burdened by a relevant physical and psychic comorbidity and frequently have a prescribed polypharmacy.
Abstract: In Italy, at the end of the 1970s, methadone hydrochloride was introduced for the treatment of opioid use disorder, in the form of a racemic mixture consisting of levomethadone and dextromethadone. In 2015 Levometadone was introduced, a new formulation marketed in Italy for the treatment of opioid use disorder in 2015. The article aims to bring the experience of an Italian Addiction Centre back to the use of this new formulation in the “real life” analyzing the efficacy, the trend of adverse events and pharmacological iterations in a context in which the treated population often uses besides the opiates, cocaine and alcohol, are burdened by a relevant physical and psychic comorbidity and frequently have a prescribed polypharmacy.
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2019 | 1 |
| 1976 | 1 |
| 1957 | 1 |