Topic
Dermal patch
About: Dermal patch is a research topic. Over the lifetime, 117 publications have been published within this topic receiving 2202 citations. The topic is also known as: skin patch.
Papers published on a yearly basis
Papers
TL;DR: A placebo-controlled study of a high-concentration capsaicin dermal patch (NGX-4010) for the treatment of painful HIV-DSP suggests that NGX- 4010 could provide a promising new treatment for painful HIV neuropathy.
Abstract: Background: HIV-associated distal sensory polyneuropathy (HIV-DSP) is a painful condition with limited effective treatment. Capsaicin desensitizes cutaneous nociceptors resulting in reduced pain. We report a placebo-controlled study of a high-concentration capsaicin dermal patch (NGX-4010) for the treatment of painful HIV-DSP. Methods: This double-blind multicenter study randomized 307 patients with painful HIV-DSP to receive NGX-4010 or control, a low-concentration capsaicin patch. After application of a topical anesthetic, NGX-4010 or control was applied once for 30, 60, or 90 minutes to painful areas on the feet. The primary efficacy endpoint was percent change in Numeric Pain Rating Scale (NPRS) from baseline in mean “average pain for past 24 hours” scores from weeks 2 to 12. Results: A single NGX-4010 application resulted in a mean pain reduction of 22.8% during weeks 2 to 12 as compared to a 10.7% reduction for controls (p = 0.0026). Following a transient treatment-related pain increase, pain was reduced; significant improvement was apparent by week 2 and continued throughout the controlled 12-week observation period. Mean pain reductions in the NGX-4010 30-, 60- and 90-minute groups were 27.7%, 15.9%, and 24.7% (p = 0.0007, 0.287, and 0.0046 vs control). One third of NGX-4010-treated patients reported ≥30% pain decrease from baseline as compared to 18% of controls (p = 0.0092). Self-limited, mild-to-moderate local skin reactions were commonly observed. Conclusions: A single NGX-4010 application was safe and provided at least 12 weeks of pain reduction in patients with HIV-associated distal sensory polyneuropathy. These results suggest that NGX-4010 could provide a promising new treatment for painful HIV neuropathy.
313 citations
TL;DR: In vitro and in vivo data demonstrate that the piezoelectric patch promotes the wound healing process through enhanced cellular metabolism, migration, and protein synthesis.
Abstract: Current treatments for wound healing engage in passive healing processes and rarely participate in stimulating skin cell behaviors for active wound healing Electric potential difference-derived electrical fields (EFs) are known to modulate skin cell behaviors Here, a piezoelectric dermal patch is developed that can be applied on skin wound site and EF is generated to promote wound healing The one-directionally aligned zinc oxide nanorod-based piezoelectric patch generates piezoelectric potential upon mechanical deformations induced by animal motion, and induces EF at the wound bed In vitro and in vivo data demonstrate that the piezoelectric patch promotes the wound healing process through enhanced cellular metabolism, migration, and protein synthesis This modality may lead to a clinically relevant piezoelectric dermal patch therapy for active wound healing
164 citations
TL;DR: It can be concluded that the monolayer film acts as a water-permeable transdermal/dermal patch on application to the skin, and the permeation kinetics across the skin was not linear, but the patch acted as a matrix controlling drug delivery.
110 citations
Patent•
30 Mar 1993
TL;DR: In this article, an improved method and apparatus for collecting analytes on a dermal patch, where the patch controls the ionization state of the analyte, was presented. But this method requires significant back-diffusion of analytes.
Abstract: The invention is an improved method and apparatus for collecting analytes on a dermal patch, where the patch controls the ionization state of the analyte. This can be accomplished by delivering electricity to the patch or by a buffer or other means for controlling the pH of fluids entering the patch. Analytes in perspiration can be concentrated on the patch without the occurrence of significant back-diffusion of the analytes.
104 citations
TL;DR: In this article, the authors describe the fabrication of an adhesive bandage comprised of multiple compliant polydimethylsiloxane (PDMS) micro-fluidic elements to perform controlled and nonintrusive transdermal sampling of glucose, or any other bio-molecule present in interstitial fluids.
Abstract: This paper describes the fabrication of an adhesive bandage comprised of multiple, compliant polydimethylsiloxane (PDMS) micro-fluidic elements to perform controlled and non-intrusive transdermal sampling of glucose, or any other bio-molecule present in interstitial fluids. The patch-like device, to be worn on the skin, has PDMS component layers that form vertically oriented micro-fluidic channels and reservoirs. In addition, micro-heater elements are integrated onto the PDMS layer that will be in contact with the skin, and are used to thermally ablate tiny micro-pores through only the dead-skin layer, allowing for easier diffusion of normally trapped bio-molecules, such as glucose, to the skin surface. The dermal patch, containing micro-channels and fluid-encapsulated reservoirs, assist in the transport of glucose molecules from just beneath the dead-skin layer to a colorimetric detection membrane situated on top of the bi-layer PDMS patch. This paper will focus on the fabrication of the prototype PDMS patch and the challenges encountered during wafer-scale batch production. Preliminary in vitro studies using human graft skin samples are included to illustrate the non-inflammatory micro-ablation procedure.
88 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 5 |
| 2020 | 8 |
| 2019 | 6 |
| 2018 | 9 |
| 2017 | 10 |
| 2016 | 7 |