TL;DR: The authors used MEDLINE to find relevant English-language literature published in the period 1999 to 2005 to identify studies describing etiology, prevalence, clinical features, controlled clinical trials of treatments and relevant laboratory research on mechanisms of action.
Abstract: Background The objective of this review is to inform practitioners about dentin hypersensitivity (DH) and its management. This clinical information is described in the context of the underlying biology. Types of Studies Reviewed The authors used MEDLINE to find relevant English-language literature published in the period 1999 to 2005. They used combinations of the search terms “dentin*,” “tooth,” “teeth,” “hypersensit*,” “desensiti*” and “desensitiz*.” They read abstracts and then full articles to identify studies describing etiology, prevalence, clinical features, controlled clinical trials of treatments and relevant laboratory research on mechanisms of action. Results The prevalence of DH varies widely, depending on the mode of investigation. Potassium-containing toothpastes are the most widely used at-home treatments. Most in-office treatments employ some form of “barrier,” either a topical solution or gel or an adhesive restorative material. The reported efficacy of these treatments varies, with some having no better efficacy than the control treatments. Possible reasons for this variability are discussed. A flowchart summarizes the various treatment strategies. Clinical Implications DH is diagnosed after elimination of other possible causes of the pain. Desensitizing treatment should be delivered systematically, beginning with prevention and at-home treatments. The latter may be supplemented with in-office modalities.
TL;DR: A series of studies are described that provide evidence that the main cause of dentinal pain is a rapid outward flow of fluid in the dentinal tubules that is initiated by strong capillary forces.
TL;DR: Recently, several therapeutic approaches to tubule occlusion have been developed which show promise as dentin desensitizing agents and blind clinical trials should be done to evaluate the efficacy of these therapies.
TL;DR: Evaluating the ability of agents used previously for clinical dentin desensitization to reduce the rate of fluid flow through dentin in vitro provided a useful quantitative method for screening a host of preparations that have been used in the past to decrease dentin sensitivity.
Abstract: The hydrodynamic theory of dentin sensitivity states that a stimulus applied at the orifice of exposed dentinal tubules causes movement of tubular fluid which stimulates nerve receptors. The fluid should obey principles of fluid movement through capillary tubes. Any decrease in the functional radius of the dentinal tubules should greatly reduce the rate of fluid flow, thus reducing dentinal sensitivity. The purpose of this study was to evaluate the ability of agents that have been used previously for clinical dentin desensitization to reduce the rate of fluid flow through dentin in vitro. Dentin discs prepared from extracted human third molars were treated with 50% citric acid to remove debris from tubular orifices. After placing the discs in a split chamber device, the rate at which buffer solution could filter across the dentin under 240 cm of water pressure was measured. The occlusal side of the disc was then treated with an agent thought to desensitize dentin to determine if it reduced fluid flow rate. Discs that had more than a 50% reduction in flow rate were examined by scanning electron microscopy to determine if those agents that decreased fluid flow also partially occluded tubular orifices. This in vitro model provided a useful quantitative method for screening a host of preparations that have been used in the past to decrease dentin sensitivity.
TL;DR: Evidence-based principles that could help optimize dentin bonding for indirect composite and porcelain restorations and the so-called immediate dentin sealing (IDS) appears to achieve improved bond strength, fewer gap formations, decreased bacterial leakage, and reduced dentin sensitivity.
Abstract: The purpose of this article is to review evidence-based principles that could help optimize dentin bonding for indirect composite and porcelain restorations. More than 30 articles were reviewed, most of them addressing the specific situation of dentin bonding for indirect restorations. It appears that the combined results of this data plus clinical experience suggest the need for a revision in the dentin bonding procedure. Immediate application and polymerization of the dentin bonding agent to the freshly cut dentin, prior to impression taking, is recommended. This new application procedure, the so-called immediate dentin sealing (IDS), appears to achieve improved bond strength, fewer gap formations, decreased bacterial leakage, and reduced dentin sensitivity. The use of filled adhesive resins (low elastic modulus liner) facilitates the clinical and technical aspects of IDS. This rational approach to adhesion also has a positive influence on tooth structure preservation, patient comfort, and long-term survival of indirect bonded restorations. CLINICAL SIGNIFICANCE Tooth preparation for indirect bonded restorations (eg, composite/ceramic inlays, onlays, and veneers) can generate significant dentin exposures. It is recommended to seal these freshly cut dentin surfaces with a dentin bonding agent (DBA) immediately following tooth preparation, before taking impression. A three-step total-etch DBA with a filled adhesive resin is recommended for this specific purpose. The major advantages, as well as the technical challenges of this procedure, are presented in detail.