TL;DR: It is demonstrated that dendrite self-avoidance in Drosophila da sensory neurons requires cell-recognition molecules encoded by the Dscam locus, which encodes a vast number of cell-surface proteins of the immunoglobulin superfamily.
TL;DR: In this issue of Neuron, Liao and colleagues (2018) uncover a surprising way that the guidance molecule MIG14/Wntless operates in dendrite self-avoidance in sensorimotor neurons.
TL;DR: An unexpected, cell-autonomous role of the Wnt-secretory factor MIG-14/Wntless in mediating dendrite self-avoidance in the C. elegans multidendritic PVD neurons is reported, and it is demonstrated that Mig-14 engages Wiskott-Aldrich syndrome protein (WASP)-dependent actin assembly to regulate dendrites self- avoidance.
TL;DR: A role is reported for the secreted molecule Slit2 and its receptor Robo2 in self-avoidance of cerebellar Purkinje cells and their deletion leads to excessive dendrite self-crossing without affecting arbor size and shape.
TL;DR: It is demonstrated that the LKB1-SIK kinase pathway plays a pivotal role in the self-avoidance of Purkinje cell (PC) dendrites by ensuring dendritic localization of Robo2, a regulator of self- avoidance.