Topic
Daidzin
About: Daidzin is a research topic. Over the lifetime, 760 publications have been published within this topic receiving 23642 citations. The topic is also known as: Daidzein 7-glucoside & Daidzoside.
Papers published on a yearly basis
Papers
TL;DR: The concentration and distribution of isoflavones in 29 commercial soybean foods, categorized into soy ingredients, traditional and second-generation, were evaluated by high-performance liquid chromatography and photodiode array detection as mentioned in this paper.
Abstract: The concentration and distribution of isoflavones in 29 commercial soybean foods, categorized into soy ingredients, traditional and second-generation, were evaluated by high-performance liquid chromatography and photodiode array detection. Twelve isomers were quantified, three aglycons (daidzein, genistein, glycitein) and nine glucosides (daidzin, genistin, glycitin; 6"-O-acetyldaidzin, -genistin, -glycitin; 6"-O-malonyldaidzin, -genistin, -glycitin). Compared with unprocessed soybeans, high-protein soy ingredients contained similar concentrations, except alcohol-leached soy concentrate. Traditional soybean foods showed differences between nonfermented and fermented foods. Nonfermented foods had greater levels of glucosides, while in contrast, greater levels of aglycons were found in fermented foods. Second-generation soy foods contained only 6-20% of the isoflavones of whole soybeans. The variety of soybean, method of processing, and addition of other components affect the retention and distribution of isoflavone isomers in soy foods.
1,084 citations
TL;DR: The efficiency of the extraction of soy isoflavones was improved by ultrasound but was dependent on the solvent employed, and the ratios of sample quantity to solvent volume and length of extraction time were improved.
560 citations
TL;DR: Examination of their abilities to enhance the resistance of low density lipoproteins to oxidation supports the observation that genistein is the most potent antioxidant among this family of compound studied, both in the aqueous and in the lipophilic phases.
Abstract: The aim of this work was to determine the antioxidant activities of a range of phytoestrogenic isoflavones. The antioxidant activity in the aqueous phase was determined by means of the ABTS.+ total antioxidant activity assay. The results show that the order of reactivity in scavenging the radical in the aqueous phase is genistein > daidzein = genistin approximately equal to biochanin A = daidzin > formononetin approximately equal to ononin, the latter displaying no antioxidant activity. The importance of the single 4'-hydroxyl group in the reactivity of the isoflavones, as scavengers of aqueous phase radicals, as well as the 5'7-dihydroxy structure is demonstrated. Examination of their abilities to enhance the resistance of low density lipoproteins to oxidation supports the observation that genistein is the most potent antioxidant among this family of compound studied, both in the aqueous and in the lipophilic phases.
501 citations
TL;DR: Humans have acquired an ability to exclusively synthesize S-equol from the precursor soy isoflavone daidzein, and it is significant that this enantiomer has a relatively high affinity for estrogen receptor beta.
485 citations
TL;DR: Anti-platelet activity and cytotoxicity of the metabolites of flavonoid glycosides by human intestinal bacteria were more effective than those of the parental compounds.
Abstract: Flavonoid glycosides were metabolized to phenolic acids via aglycones by human intestinal microflora producing alpha-rhamnosidase, exo-beta-glucosidase, endo-beta-glucosidase and/or beta-glucuronidase. Rutin, hesperidin, naringin and poncirin were transformed to their aglycones by the bacteria producing alpha-rhamnosidase and beta-glucosidase or endo-beta-glucosidase, and baicalin, puerarin and daidzin were transformed to their aglycones by the bacteria producing beta-glucuronidase, C-glycosidase and beta-glycosidase, respectively. Anti-platelet activity and cytotoxicity of the metabolites of flavonoid glycosides by human intestinal bacteria were more effective than those of the parental compounds. 3,4-Dihydroxyphenylacetic acid and 4-hydroxyl-phenylacetic acid were more effective than rutin and quercetin on anti-platelet aggregation activity. 2,4,6-Trihydroxybenzaldehyde, quercetin and ponciretin were more effective than rutin and ponciretin on the cytotoxicity for tumor cell lines. We insist that these flavonoid glycosides should be natural prodrugs.
406 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 6 |
| 2024 | 15 |
| 2023 | 23 |
| 2022 | 47 |
| 2021 | 17 |
| 2020 | 31 |