Topic
Dacrocyte
About: Dacrocyte is a research topic. Over the lifetime, 5 publications have been published within this topic receiving 43 citations. The topic is also known as: Teardrop Cells.
Papers
1 Nov 2019
TL;DR: A proposed system is aimed to support medical technicians, hematologist, and pathologist in identifying RBC by creating a device using Raspberry Pi that can measure the different parameter of the RBC such as area, perimeter, diameter, shape geometric factor (SGF), and detecting the central pallor and target flag.
Abstract: Blood is an important liquid that supports performs important functions for human. The general components of human blood are RBCs, WBCs, plasma, and platelets. Whereas, RBCs occupies the largest volume in blood. RBCs can be healthy or unhealthy. An unhealthy or abnormal red blood cells indicates blood related disorders, such as Anemia. RBCs can be determined by variations in size, shape, and color. The method in evaluating RBC is through conventional microscopy which leads to misreport results and experts are given hefty workload. A proposed system is aimed to support medical technicians, hematologist, and pathologist in identifying RBC by creating a device using Raspberry Pi that can measure the different parameter of the RBC such as area, perimeter, diameter, shape geometric factor (SGF), and detecting the central pallor and target flag. Related studies were already conducted using different approach one study uses Artificial Neural Network (ANN) in classifying RBC with an accuracy 90.54%. Another study uses radial basis function network it obtained an accuracy of 83.3%. With the proposed system using Support Vector Machine (SVM) classifier it acquired an accuracy of 93.33% in identifying 7 different red blood cells such as normal, echinocytes, elliptocytes, dacrocytes, spherocytes, target cell, stomatocytes, and identifying unknown cells. The classification of RBC helps in diagnosing different types of anemia such as iron-deficiency anemia, thalassemia, hereditary spherocytosis, and myelophthisic anemia. This system serves only as an aid for doctors for early diagnosis of identifying abnormal red blood cells and succeeding laboratory exams must be done to finally conclude a disease associated to abnormal RBCs.
44 citations
TL;DR: High circulating CD34 cell count, the presence of clonal platelets and granulocytes and of peripheral-blood dacrocytes, and a JAK2 1849G>T (V617F) mutation are intrinsic features ofClonal progenitors present in patients with myelofibrosis due to myeloproliferative disorders and that these features are not due to the abnormal marrow architecture seen in secondary myel ofibrosis.
34 citations
TL;DR: A role for the spleen and for extramedullary hematopoiesis in the pathogenesis of this distinctive red cell morphologic abnormality is supported.
Abstract: The presence of teardrop-shaped red cells in peripheral blood has traditionally been felt to reflect altered marrow architecture, namely myelofibrosis. We evaluated two patients with splenomegaly, moderately severe hemolytic anemia due to warm-reactive IgG anti-red cell autoantibody, and bone marrow erythroid hyperplasia without myelofibrosis. A striking predominance of teardrop-shaped red cells was noted upon examination of their blood films. Removal of a spleen containing extramedullary hematopoiesis in one and resolution of splenomegaly in the other were accompanied by disappearance of these cells. Our observations support a role for the spleen and for extramedullary hematopoiesis in the pathogenesis of this distinctive red cell morphologic abnormality.
13 citations
TL;DR: A high circulating CD34 count, clonal platelets and granulocytes, presence of dacrocytes, and JAK2 1849G>T (V617F) mutation of clonal progenitors are the intrinsic features present in patients with myel ofibrosis due to myeloproliferative disorders and that these features are not due to the abnormal marrow architecture that is seen in secondary myelofibrosis.
2 citations
20 Apr 2016
TL;DR: The results do not support the theory asserting that dacrocyte formation is a result of splenomegaly since only 28.5% of patients with this erythrocyte anomaly presented associated splenomesgaly, but may be present, at a very low prevalence, in various systemic diseases.
Abstract: Background: Dacrocytes or “teardrop cells” are elongated red blood cells at one end forming a cell with the appearance of a tear drop and are of varying size. Dacrocytes are frequently observed in complete blood counts of patients with myeloproliferative disease, but can also be found in other systemic diseases in which their prevalence and clinical significance remains unknown.
Objective: To evaluate the prevalence and possible clinical significance of dacrocytes observed in the peripheral blood smear of patients with different systemic diseases.
Methods: This is a descriptive study that analyzed the peripheral blood smears of 35,086 patients in a tertiary care hospital, in search of dacrocytes, and correlating this finding with their clinical and biochemical profiles.
Results: Dacrocytes were intentionally sought in 35,086 peripheral blood smears. The observed prevalence of dacrocytosis was 1.4% (n=492 patients). No statistically significant relationship was established between dacrocytosis and the patients’ diagnoses, although there was a tendency to find dacrocytes in patients with cancer (CA) and systemic lupus erythematosus (SLE). Thus the presence of dacrocytes was not associated to the type of anemia or to the degree of renal dysfunction. Our results do not support the theory asserting that dacrocyte formation is a result of splenomegaly since only 28.5% of patients with this erythrocyte anomaly presented associated splenomegaly.
Conclusion: Dacrocytosis may be present, at a very low prevalence, in various systemic diseases. It is independent of the type of anemia and the degree of renal dysfunction. For the first time, splenomegaly is excluded as the only cause of dacrocytosis in peripheral blood smears.
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2019 | 1 |
| 2016 | 1 |
| 2006 | 1 |
| 2005 | 1 |
| 1986 | 1 |