About: Cutaneous structure development is a research topic. Over the lifetime, 4 publications have been published within this topic receiving 136 citations.
TL;DR: Epithelial organs such as the vertebrate hair control periodic self-renewal by regulating the growth of progenitor cells in other organs by regulation of Sonic hedgehog signaling.
TL;DR: An assortment of stem cell markers have been identified that permit assignment of stem cells to specific regions of the epidermis, and progress has been made in understanding the role of these cells in normal epidermal homeostasis and in conditions of tissue stress.
TL;DR: In this review, the major experiments that have contributed to the understanding of the epidermal stem cells and the control of their fate are described.
Abstract: The epidermis consists of three actively proliferating units, the interfollicular epidermis, the hair follicle, and the sebaceous gland. Stem cells in the epidermis have the capacity to produce all three of these units. The fate of the epidermal stem cells and some of their progeny can be altered, dependent on the environment in which they reside and the genes they express. In this review, we describe the major experiments that have contributed to the understanding of the epidermal stem cells and the control of their fate.