Topic
Cribriform
About: Cribriform is a research topic. Over the lifetime, 312 publications have been published within this topic receiving 6509 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: Of patients who eventually died of tumor, those having “tubular” predominant lesions had the longest course (average 9 years before death, in contrast to 8 years for the “cribriform” and 5 years forThe “solid” tumors).
Abstract: 62 cases of adenoid cystic carcinoma (ACC) arising in major and minor salivary glands were studied. Factors which appeared to influence the clinical course included: 1) histologic pattern, 2) presence or absence of tumor on the surgical lines of excision, 3) site, 4) size of primary lesion, 5) presence or absence of tumor in lymph nodes, and 6) degree of cellular atypia. On histologic examination, these neoplasms were classified according to their predominant histologic pattern (tubular, cribriform or solid). Recurrences have been seen in 59% of patients with ACC demonstrating a predominantly “tubular” pattern, as compared to 89% for the “cribriform” lesions and 100% for the “solid” neoplasms. Of patients who eventually died of tumor, those having “tubular” predominant lesions had the longest course (average 9 years before death, in contrast to 8 years for the “cribriform” and 5 years for the “solid” tumors). Our findings suggest that the “tubular” predominant pattern has the best prognosis and represents the best differentiated histologic form of ACC. In contrast, the “solid” pattern is the least differentiated and is associated with the worst prognosis. The predominantly “cribriform” lesions appear to lie between the other two forms both clinically and histologically.
517 citations
TL;DR: Cribriform growth in Gleason grade 4 is a strong prognostic marker for distant metastasis and disease-specific death in patients with Gleason score 7 prostate cancer at radical prostatectomy.
285 citations
TL;DR: The effect of TGFbeta, a growth factor increased in aqueous humor of glaucomatous eyes and glycocorticoids on trabecular meshwork cells show typical changes in formation of extracellular matrix components and of stress proteins.
262 citations
TL;DR: The observation by de Coster that the distance from sella turcica to foramen caecum does not increase after eruption of the first permanent molar teeth is confirmed and the merits of the cribriform plane and the nasion-sella line as base lines for serial radiographic studies of the developing skull are discussed.
230 citations
TL;DR: Regrading cribriform cancer as Gleason 5 improved the grade association with failure, although half of all cases with individual cells also had a cribr Uniform pattern, precluding a precise determination of the independent importance of the latter.
Abstract: Proper grading of the cribriform prostate cancer pattern has not previously been supported by outcome-based evidence. Among 153 men who underwent radical prostatectomy, 76 with prostate-specific antigen (PSA) failure (≥0.2 ng/mL [0.2 μg/L]) were matched to 77 without failure. Frequencies of high-grade patterns included fused small acini, 83.7%; papillary, 52.3%; large cribriform, 37.9%; small (≤12 lumens) cribriform, 17.0%; and individual cells, 22.9%. A cribriform pattern was present in 61% (46/76) of failures but 16% (12/77) of nonfailures (P < .0001). Multivariate analysis showed the cribriform pattern had the highest odds ratio for PSA failure, 5.89 (95% confidence interval, 2.53-13.70; P < .0001). The presence of both large and small cribriform patterns was significantly linked to failure. The cumulative odds ratio of failure per added square millimeter of cribriform pattern was 1.173 (P = .008), higher than for any other pattern. All 8 men with a cribriform area sum of 25 mm(2) or more had failure (range, 33-930). Regrading cribriform cancer as Gleason 5 improved the grade association with failure, although half of all cases with individual cells also had a cribriform pattern, precluding a precise determination of the independent importance of the latter. The cribriform pattern has particularly adverse implications for outcome.
204 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 32 |
| 2024 | 45 |
| 2023 | 104 |
| 2022 | 71 |
| 2021 | 21 |
| 2020 | 22 |