Topic
Colon polyps
About: Colon polyps is a research topic. Over the lifetime, 1087 publications have been published within this topic receiving 25106 citations.
Papers published on a yearly basis
Papers
TL;DR: The results of the National Polyp Study support the view that colorectal adenomas progress to adenocarcinomas, as well as the current practice of searching for and removing adenomatous polyps to prevent coloreCTal cancer.
Abstract: Background The current practice of removing adenomatous polyps of the colon and rectum is based on the belief that this will prevent colorectal cancer. To address the hypothesis that colonoscopic polypectomy reduces the incidence of colorectal cancer, we analyzed the results of the National Polyp Study with reference to other published results. Methods The study cohort consisted of 1418 patients who had a complete colonoscopy during which one or more adenomas of the colon or rectum were removed. The patients subsequently underwent periodic colonoscopy during an average follow-up of 5.9 years, and the incidence of colorectal cancer was ascertained. The incidence rate of colorectal cancer was compared with that in three reference groups, including two cohorts in which colonic polyps were not removed and one general-population registry, after adjustment for sex, age, and polyp size. Results Ninety-seven percent of the patients were followed clinically for a total of 8401 person-years, and 80 percent returned...
4,697 citations
Duke University1, Veterans Health Administration2, University of California, San Francisco3, University of Texas at Austin4, VCU Medical Center5, University of Chicago6, University of Medicine and Dentistry of New Jersey7, University of Texas Medical Branch8, California Pacific Medical Center9, University of California, San Diego10, New York University11
TL;DR: Colonoscopy was more sensitive than other tests, as currently undertaken, for detection of colonic polyps and cancers, and have important implications for diagnostic use of colon imaging tests.
653 citations
TL;DR: The results suggest that self-reports of some diseases can be taken as accurate, but self- Reports of other conditions might require medical record verification in epidemiologic follow-up studies.
Abstract: The authors compared interview reports with hospitalization records of participants in a nationally representative survey to determine the accuracy of self-reports of ischemic heart disease, stroke, gallbladder disease, ulcers, cataract, hip fracture, colon polyps, and cancers of the colon, breast, prostate, and lung. The study cohort consisted of 10,523 participants from the First National Health and Nutrition Examination Survey in 1971-1975 who were aged 25-74 years at the baseline examination and who completed a follow-up interview in 1982-1984. Self-reports of hospitalization for breast cancer were confirmed as accurate for 100% of cases where a hospital record was available. Self-report accuracy was also high for ischemic heart disease (84%), cataract (83%), and hip fracture (81%); it was moderate for lung cancer (78%), prostate cancer (75%), gallbladder disease (74%), colon cancer (7l %), and stroke (67%); but it was low for ulcers (54%) and colon polyps (32%). Some of the self-reports of ulcers (20%), hip fracture (9%), ischemic heart disease (7%), and stroke (7%) were found to reflect diagnoses of other conditions of anatomic proximity. Accuracy of self-reports improved with higher levels of education, but was not generally related to age, gender, race, alcohol use, or smoking. The results suggest that self-reports of some diseases can be taken as accurate, but self-reports of other conditions might require medical record verification in epidemiologic follow-up studies.
364 citations
TL;DR: The effectiveness of a CADe system that avoids potential operational bias during colonoscopy is assessed in a double-blind randomised trial at the endoscopy centre in Caotang branch hospital of Sichuan Provincial People's Hospital in China.
353 citations
TL;DR: Serrated adenocarcinoma is a recently described, distinct variant of CRC, characterized by early involvement of oncogenic BRAF mutations, excess CpG island methylation (CIM) and subsequent low‐ or high‐level DNA microsatellite instability (MSI).
Abstract: Colorectal cancer (CRC) ranks among the three most common cancers in terms of both cancer incidence and cancer-related deaths in most Western countries. Serrated adenocarcinoma is a recently described, distinct variant of CRC, accounting for about 7.5% of all CRCs and up to 17.5% of most proximal CRCs. It has been postulated that about 10-15% of sporadic CRCs would have their origin in serrated polyps that harbour a significant malignant potential. These lesions include hyperplastic-type aberrant crypt foci, hyperplastic polyps, sessile serrated adenomas, admixed polyps and serrated adenomas, and constitute the so-called 'serrated pathway', which is distinct from both the conventional adenoma-carcinoma pathway and the mutator pathway of hereditary non-polyposis CRC and is characterized by early involvement of oncogenic BRAF mutations, excess CpG island methylation (CIM) and subsequent low- or high-level DNA microsatellite instability (MSI). Methylation of hMLH1 is likely to explain the increased frequency of high-level MSI (16%) and methylation of MGMT is postulated to explain the low-level MSI (29%) in serrated adenocarcinomas. Reproducible histopathological criteria for serrated adenocarcinoma have recently been established and they have been qualified by DNA expression analysis for 7928 genes, showing clustering of serrated adenocarcinomas into a molecular entity apart from conventional adenocarcinoma, and representing with distinct down-regulation of EPHB2, PTCH and up-regulation of HIF1alpha.
339 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2022 | 1 |
| 2021 | 71 |
| 2020 | 57 |
| 2019 | 53 |
| 2018 | 50 |
| 2017 | 54 |