TL;DR: The application of NIRS to the detection and identification of changes in uncoated and coated tablets in response to pilot-scale changes in process parameters during melt granulation, compression, and coating is described.
TL;DR: In this article, the authors present novel pharmaceutical aerosol formulations comprising: (a) a therapeutic agent in the form of particles coated by at least one coating excipient, in suspension in a liquefied propellant gas for the administration of therapeutic agents particularly by the pulmonary route and to a process for preparing these formulations.
Abstract: The present invention relates to novel pharmaceutical aerosol formulations comprising: (A) a therapeutic agent in the form of particles coated by at least one coating excipient and at least one surfactant, in suspension in (B) a liquefied propellant gas for the administration of therapeutic agents particularly by the pulmonary route and to a process for preparing these formulations It also relates to novel particles suitable for use in such formulations
TL;DR: In this paper, the authors present novel pharmaceutical aerosol formulations comprising salmeterol xinafoate in the form of particles coated by spray-drying with at least one surfactant in the absence of any other coating excipient, in suspension in a liquefied propellant gas.
Abstract: The present invention relates to novel pharmaceutical aerosol formulations comprising: (A) salmeterol xinafoate in the form of particles coated by spray-drying with at least one surfactant in the absence of any other coating excipient, in suspension in (B) a liquefied propellant gas which is 1, 1, 1, 2, 3, 3, 3-heptafluoro-n-propane or 1, 1, 1, 2-tetrafluoroethane and mixtures thereof for administration particularly by the pulmonary route and to a process for preparing these formulations. It also relates to novel particles suitable for use in such formulations.
TL;DR: In this article, the use of a particle-containing powdery coating material, wherein the surface of the particles is at least partially covered with a coating excipient, in cold spraying, flame spraying, high velocity flame spraying and plasma thermal spraying, and non-thermal plasma spraying, is described.
Abstract: Die vorliegende Erfindung betrifft die Verwendung eines Partikel-haltigen pulverformigen Beschichtungsmaterials, wobei die Oberflache der Partikel zumindest teilweise mit einem Beschichtungshilfsstoff belegt ist, beim Kaltgasspritzen, Flammspritzen, Hochgeschwindigkeitsflammspritzen, thermischen Plasmaspritzen und nichtthermischen Plasmaspritzen. The present invention relates to the use of a particle-containing powdery coating material, wherein the surface of the particles is at least partially covered with a coating excipient, in cold spraying, flame spraying, high velocity flame spraying, plasma thermal spraying, and non-thermal plasma spraying. Ferner betrifft die vorliegende Erfindung Beschichtungsverfahren, insbesondere die vorgenannten Verfahren, unter Einsatz des erfindungsgemasen pulverformigen Beschichtungsmaterials. The present invention coating process, especially the above-mentioned methods, with the use of the powdery coating material of the invention also relates.
TL;DR: In this paper, a self-emulsifying composition comprising, relative to 100 parts by weight of a solid preparation, 0.1-0.5 parts of dutasteride, 6-110 parts of oil, and 6-120 parts of a surfactant was presented.
Abstract: The present invention provides: a self-emulsifying composition comprising, relative to 100 parts by weight of a solid preparation, 0.1-0.5 parts by weight of dutasteride, 6-110 parts by weight of oil, and 6-110 parts by weight of a surfactant; a solid preparation comprising 5-185 parts by weight of a coating excipient comprising pores formed in a surface thereof, the self-emulsifying composition being accommodated in the pores; and a method for preparing the solid preparation.