Topic
Clostebol
About: Clostebol is a research topic. Over the lifetime, 20 publications have been published within this topic receiving 504 citations. The topic is also known as: Clostebol.
Papers
TL;DR: Exretion studies with the most common anabolic steroids were performed and the main excreted metabolites were synthesized for bolasterone, boldenone, 4-chlorodehydromethyltestosterone, clostebol, drostanolone, fluoxymesterone, formebol one, mestanolone, mesterolone and metandienone.
294 citations
TL;DR: In this paper, gas chromatography-mass spectrometry revealed the presence of nandrolone metabolites in the urine of untreated persons, and the assumption was that such findings could be related to the consumption of meat from animals treated with Nandrolones.
36 citations
TL;DR: Monitoring of S1a improves the detection time of clostebol misuse with respect to the commonly monitored metabolites, excreted in the glucuronide fraction, and this new metabolite can be incorporated into recently developed LC-MS/MS screening methods base on the direct detection of phase II metabolites.
30 citations
TL;DR: In this paper, a micellar liquid chromatography (MLC) based method for the determination of banned drugs in sport (including stimulants, anabolic steroids and diuretics) is proposed.
27 citations
TL;DR: In this study, clostebol metabolic profiles were investigated carefully and nine unreported metabolites (two free ones and seven sulfate conjugates) were identified by MS, and their potential structures were proposed based on fragmentation and metabolism pathways.
Abstract: In this study, clostebol metabolic profiles were investigated carefully. Clostebol was administered to one healthy male volunteer. Urinary extracts were analyzed by liquid chromatography quadrupole time-of-flight mass spectrometry (MS) using full scan and targeted MS/MS techniques with accurate mass measurement for the first time. Liquid–liquid extraction and direct injection were applied to processing urine samples. Chromatographic peaks for potential metabolites were found by using the theoretical [M–H]− as target ion in full scan experiment, and their actual deprotonated ions were analyzed in targeted MS/MS mode. Fourteen metabolites were found for clostebol, and nine unreported metabolites (two free ones and seven sulfate conjugates) were identified by MS, and their potential structures were proposed based on fragmentation and metabolism pathways. Four glucuronide conjugates were also first reported. All the metabolites were evaluated in terms of how long they could be detected and S1 (4ξ-chloro-5ξ-androst-3ξ-ol-17-one-3ξ-sulfate) was considered to be the long-term metabolite for clostebol misuse detected up to 25 days by liquid–liquid extraction and 14 days by direct injection analysis after oral administration. Five conjugated metabolites (M2, M5, S2, S6 and S7) could also be the alternative biomarkers for clostebol misuse. Copyright © 2015 John Wiley & Sons, Ltd.
24 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 2 |
| 2019 | 1 |
| 2016 | 1 |
| 2015 | 1 |
| 2013 | 1 |
| 2010 | 1 |