Topic
Clockwork
About: Clockwork is a research topic. Over the lifetime, 215 publications have been published within this topic receiving 4593 citations.
Papers published on a yearly basis
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Papers
TL;DR: It is shown in the regenerating liver (of mice) that the circadian clock controls the expression of cell cycle–related genes that in turn modulate theexpression of active Cyclin B1-Cdc2 kinase, a key regulator of mitosis.
Abstract: Cell division in many mammalian tissues is associated with specific times of day, but just how the circadian clock controls this timing has not been clear. Here, we show in the regenerating liver (of mice) that the circadian clock controls the expression of cell cycle-related genes that in turn modulate the expression of active Cyclin B1-Cdc2 kinase, a key regulator of mitosis. Among these genes, expression of wee1 was directly regulated by the molecular components of the circadian clockwork. In contrast, the circadian clockwork oscillated independently of the cell cycle in single cells. Thus, the intracellular circadian clockwork can control the cell-division cycle directly and unidirectionally in proliferating cells.
1,175 citations
320 citations
TL;DR: The field is now poised to elucidate these computations, their underlying cellular mechanisms, and how the SCN clock interacts with subordinate circadian clocks across the brain to determine the timing and efficiency of the sleep-wake cycle, andHow perturbations of this coherence contribute to neurological and psychiatric illness.
Abstract: The suprachiasmatic nucleus (SCN) is the principal circadian clock of the brain, directing daily cycles of behavior and physiology. SCN neurons contain a cell-autonomous transcription-based clockwork but, in turn, circuit-level interactions synchronize the 20,000 or so SCN neurons into a robust and coherent daily timer. Synchronization requires neuropeptide signaling, regulated by a reciprocal interdependence between the molecular clockwork and rhythmic electrical activity, which in turn depends on a daytime Na+ drive and nighttime K+ drag. Recent studies exploiting intersectional genetics have started to identify the pacemaking roles of particular neuronal groups in the SCN. They support the idea that timekeeping involves nonlinear and hierarchical computations that create and incorporate timing information through the interactions between key groups of neurons within the SCN circuit. The field is now poised to elucidate these computations, their underlying cellular mechanisms, and how the SCN clock interacts with subordinate circadian clocks across the brain to determine the timing and efficiency of the sleep-wake cycle, and how perturbations of this coherence contribute to neurological and psychiatric illness.
242 citations
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CERN1
TL;DR: The clockwork is a mechanism for generating light particles with exponentially suppressed interactions in theories which contain no small parameters at the fundamental level as discussed by the authors, which can be implemented with a discrete set of new fields or, in its continuum version, through an extra spatial dimension.
Abstract: The clockwork is a mechanism for generating light particles with exponentially suppressed interactions in theories which contain no small parameters at the fundamental level We develop a general description of the clockwork mechanism valid for scalars, fermions, gauge bosons, and gravitons This mechanism can be implemented with a discrete set of new fields or, in its continuum version, through an extra spatial dimension In both cases the clockwork emerges as a useful tool for model-building applications Notably, the continuum clockwork offers a solution to the Higgs naturalness problem, which turns out to be the same as in linear dilaton duals of Little String Theory We also elucidate the similarities and differences of the continuum clockwork with large extra dimensions and warped spaces All clockwork models, in the discrete and continuum, exhibit novel phenomenology with a distinctive spectrum of closely spaced resonances
231 citations
194 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 24 |
| 2024 | 34 |
| 2023 | 51 |
| 2022 | 84 |
| 2021 | 7 |
| 2020 | 8 |