Topic
CKMT2
About: CKMT2 is a research topic. Over the lifetime, 11 publications have been published within this topic receiving 313 citations. The topic is also known as: SMTCK & creatine kinase, mitochondrial 2.
Papers
TL;DR: The results demonstrate that free radical-mediated alteration of energy metabolism is an important mechanism mediating DOX-induced cardiac injury, suggesting that metabolic intervention may represent a novel approach to preventing cardiac injury after chemotherapy.
108 citations
TL;DR: The first comparative proteotype analysis of primary human brown adipose tissue versus adjacent white adiposes tissue is presented, which reveals significant quantitative differences in protein abundances and in turn differential functional capabilities.
Abstract: Human brown adipose tissue (BAT) has become an attractive target to combat the current epidemical spread of obesity and its associated co-morbidities. Currently, information on its functional role is primarily derived from rodent studies. Here, we present the first comparative proteotype analysis of primary human brown adipose tissue versus adjacent white adipose tissue, which reveals significant quantitative differences in protein abundances and in turn differential functional capabilities. The majority of the 318 proteins with increased abundance in BAT are associated with mitochondrial metabolism and confirm the increased oxidative capacity. In addition to uncoupling protein 1 (UCP1), the main functional effector for uncoupled respiration, we also detected the mitochondrial creatine kinases (CKMT1A/B, CKMT2), as effective modulators of ATP synthase coupled respiration, to be exclusively expressed in BAT. The abundant expression and utilization of both energy expenditure pathways in parallel highlights the complex functional involvement of BAT in human physiology.
64 citations
TL;DR: Several genes such as regulator of G-protein signaling 2 and IMP dehydrogenase 1 were down-regulated in the BAT of cold-exposed rats, while remarkable elevations of the transcript levels of several genes that seemed to be associated with the processes of cell-cycle regulation and DNA replication were detected, possibly reflecting the significant proliferation of brown adipocytes in response to cold exposure.
28 citations
TL;DR: It is hypothesize that enhanced expression of the energy production and transfer system in breast muscle of the high FE pedigree broiler male could be fundamentally important in the phenotypic expression of feed efficiency.
19 citations
TL;DR: YAC clones for the creatine kinase, mitochondrial 2 (sarcomeric; CKMT2), gene were isolated and a polymorphic dinucleotide repeat (heterozygosity 0.77) was identified within the seventh intron of the CK MT2 gene.
10 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2017 | 2 |
| 2016 | 2 |
| 2014 | 1 |
| 2013 | 1 |
| 2008 | 2 |