Topic
Cholestane
About: Cholestane is a research topic. Over the lifetime, 693 publications have been published within this topic receiving 8622 citations. The topic is also known as: alpha-cholestane & cholestan.
Papers published on a yearly basis
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Papers
TL;DR: The experiments indicate that the effect of sterol on the ability of saturated lipids to form a tightly packed and ordered state is the key to their effect on domain formation.
Abstract: Detergent-insoluble membrane domains, enriched in saturated lipids and cholesterol, have been implicated in numerous biological functions. To understand how cholesterol promotes domain formation, the effect of various sterols and sterol derivatives on domain formation in mixtures of the saturated lipid dipalmitoylphosphatidylcholine (DPPC) and a fluorescence quenching analogue of an unsaturated lipid was compared. Quenching measurements demonstrated that several sterols (cholesterol, dihydrocholesterol, epicholesterol, and 25-hydroxycholesterol) promote formation of DPPC-enriched domains. Other sterols and sterol derivatives had little effect on domain formation (cholestane and lanosterol) or, surprisingly, strongly inhibit it (coprostanol, androstenol, cholesterol sulfate, and 4-cholestenone). The effect of sterols on domain formation was closely correlated with their effects on DPPC insolubility. Those sterols that promoted domain formation increased DPPC insolubility, whereas those sterols that inhibit...
509 citations
TL;DR: The data indicate that lipid bilayer disruption or reorganization is involved in alcohol effects on black lipid membrane conductivity and erythrocyte antihemolysis and that anesthesia may be caused by small disruptions of lipid bilayers structure in biological membranes.
179 citations
TL;DR: Five cholestane glycosides including three new ones with potent cytostatic activity on leukemia HL -60 cells were isolated from Ornithogalum saundersiae bulbs and compound 1, a main constituent in the bulbs, was revealed to be exceptionally cytostatics against various malignant tumor cells and effective to mouse P388 leukemia in in vivo evaluation.
167 citations
TL;DR: In this paper, three new acylated cholestane glycosides were found in the bulbs of Ornithogalum saundersiae and their structures were elucidated, on the basis of the spectroscopic data and chemical evidences, and by comparing them with those of known compounds.
156 citations
TL;DR: OSW-1 (1), an acylated disaccharide cholestane saponin from Ornithogalum saudersiae with exceptionally potent antitumor activity, was first synthesized from commercially available dehydroisoandrosterone, L-arabinose, and D-xylose in total 27 steps with the longest linear sequence of 14 steps and in 6% yield.
Abstract: OSW-1 (1), an acylated disaccharide cholestane saponin from Ornithogalum saudersiae with exceptionally potent antitumor activity, was first synthesized from commercially available dehydroisoandrosterone, L-arabinose, and D-xylose in total 27 steps with the longest linear sequence of 14 steps and in 6% yield.
150 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2025 | 1 |
| 2024 | 4 |
| 2022 | 6 |
| 2021 | 5 |
| 2020 | 8 |
| 2019 | 7 |