Topic
Chemotactic selection
About: Chemotactic selection is a research topic. Over the lifetime, 18 publications have been published within this topic receiving 284 citations.
Papers
TL;DR: Three representative cytokines interleukin (IL-8), RANTES and tumour necrosis factor alpha (TNF-alpha) have a concentration-dependent chemotactic effect on the unicellular Tetrahymena, which indicates an evolutionary background of physiological effects elicited.
79 citations
Journal Article•
44 citations
TL;DR: It is shown that "chemotactic selection" of cells, by the new probe developed by us is a suitable tool to provide subpopulations possessing enhanced chemotactic receptor-effector mechanisms with respect to the selector signal molecules (IL-8, TNF-alpha).
Abstract: In this review we summarize our results gained on the investigations focused to characterize ligand and signaling mechanisms required for the Chemotaxis in the unicellular model Tetrahymena. Our data show that short chain signal molecules (amino acids, oligopeptides) are distinguished upon their physicochemical characteristics – lipophylicity, residual volumes and statistical distribution of side-chain distances (e.g. in proline containing dipeptides), while the vertebrate hormones have also specific attractant or repellent effects in the model (FSH vs. TSH). Hormonal imprinting developed by pretreatments has also special, signal molecule dependent effect (histamine vs. serotonin). It is shown that “chemotactic selection” of cells, by the new probe developed by us is a suitable tool to provide subpopulations possessing enhanced chemotactic receptor–effector mechanisms with respect to the selector signal molecules (IL-8, TNF-α).
35 citations
01 May 2000-Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology
TL;DR: Morphometric evaluation of the cells showed a good correlation between chemotactic responsiveness and morphometric characteristics of subpopulations selected with insulin and histamine, and T2 data suggest that the long lasting responsiveness is not general, but might be subpopulation specific.
22 citations
TL;DR: Study of chemotactic selection with BK derivatives supports the previous findings that only phylogenetically selected ligands or their close derivatives are able to induce long‐term selection with chemotaxis.
19 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2016 | 2 |
| 2012 | 1 |
| 2006 | 1 |
| 2003 | 3 |
| 2002 | 4 |
| 2001 | 2 |