Topic
Centralspindlin complex
About: Centralspindlin complex is a research topic. Over the lifetime, 105 publications have been published within this topic receiving 11996 citations.
Papers published on a yearly basis
Papers
TL;DR: This review provides an overview of four topics in animal cell cytokinesis: signaling between the anaphase spindle and cortex, the mechanics of cortical remodeling, abscission, and regulation of cytokineis by the cell cycle machinery.
Abstract: Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase spindle. Cytokinesis relies on a tight interplay between signaling and cellular mechanics and has attracted the attention of both biologists and physicists for more than a century. In this review, we provide an overview of four topics in animal cell cytokinesis: (a) signaling between the anaphase spindle and cortex, (b) the mechanics of cortical remodeling, (c) abscission, and (d) regulation of cytokinesis by the cell cycle machinery. We report on recent progress in these areas and highlight some of the outstanding questions that these findings bring into focus.
598 citations
TL;DR: In this paper, the N terminus of CYK-4 binds the central region of ZEN-4, including the neck linker, which is a RhoGAP domain.
549 citations
TL;DR: It is proposed that centriolin anchors protein complexes required for vesicle targeting and fusion and integrates membrane-vesicle fusion with abscission.
466 citations
TL;DR: Recent studies in animal cells have shown that local assembly of the contractile ring is mediated by a discrete pool of GTP-bound, active RhoA, and insights are allowed into the mechanisms and the molecules that promote the accumulation of active RHoA at the correct time and place in the cell.
391 citations
TL;DR: It is shown that active RhoA concentrates in a precisely bounded zone before cytokinesis and is independent of actin assembly, and it is concluded that microtubules specify the cytokinetic apparatus via a dynamic zone of local RHoA activity.
Abstract: Cytokinesis in animal cells results from the assembly and constriction of a circumferential array of actin filaments and myosin-2. Microtubules of the mitotic apparatus determine the position at which the cytokinetic actomyosin array forms, but the molecular mechanisms by which they do so remain unknown. The small GTPase RhoA has previously been implicated in cytokinesis. Using four-dimensional microscopy and a probe for active RhoA, we show that active RhoA concentrates in a precisely bounded zone before cytokinesis and is independent of actin assembly. Cytokinetic RhoA activity zones are common to four echinoderm species, the vertebrate Xenopus laevis, and the highly asymmetric cytokinesis accompanying meiosis. Microtubules direct the formation and placement of the RhoA activity zone, and the zone is repositioned after physical spindle displacement. We conclude that microtubules specify the cytokinetic apparatus via a dynamic zone of local RhoA activity.
355 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 4 |
| 2020 | 2 |
| 2019 | 8 |
| 2018 | 3 |
| 2017 | 2 |
| 2016 | 3 |