Topic
Cell theory
About: Cell theory is a research topic. Over the lifetime, 69 publications have been published within this topic receiving 3511 citations.
Papers published on a yearly basis
Papers
TL;DR: It is believed that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype.
Abstract: In the early 19th century, building on observations of microscopists now ancient, Schleiden and Schwann formulated the doctrine that cells are building blocks for plant and animal tissues (1). By the mid-19th century, Raspail, Remak, and Virchow expanded this hypothesis by suggesting that all cells come from preexisting cells — the so-called cell theory. Although referring to cell division, this now classic notion is prescient of another contemporary twist in the biology of cell maturation: beyond lineage development and normal differentiation, mature epithelial cells under new environmental pressures exhibit a local plasticity that allows them to morph into other mature phenotypes with or without proliferation (2, 3). Growing interest in the biology of these cellular transitions helped both establish epithelial cell plasticity as a field of study in the late 20th century and fashion much of the current thinking regarding morphogenesis in early embryonic development, tissue repair, and cancer metastasis (4–6). The details of some of these processes are not discussed here, as they are outlined in other articles in this Review Series on epithelial-mesenchymal transition (EMT) (7, 8). Instead, we offer a personal view gathered from our own experience and the literature regarding an approach documenting EMT events in culture or tissue. We hope this serves to stimulate other points of view as new data emerge.
2,362 citations
TL;DR: After the first observations of life under the microscope, it took two centuries of research before the 'cell theory', the idea that all living things are composed of cells or their products, was formulated.
Abstract: After the first observations of life under the microscope, it took two centuries of research before the 'cell theory', the idea that all living things are composed of cells or their products, was formulated. It proved even harder to accept that individual cells also make up nervous tissue.
308 citations
TL;DR: The current era of reductionism and emphasis on broadly generalizing principles in biology has focused on the apparent similarity of cellular subunits comprising plant and animal tissues, promoting the perception of a biological unity that transcends the major kingdoms.
Abstract: ince the publication of the cell theory (Schleiden 1838, Schwann 1839), "the cell is the building stone of the organism" (Heidenhain 1907) has become one of the great slogans in biology, influencing approaches to both teaching and research. Under the tacit assumption that organismal structure and function can best be understood by studying the subunits rather than the organism as a whole, general biology classes often begin with cell biology rather than study of the whole organism. The current era of reductionism and emphasis on broadly generalizing principles in biology has focused on the apparent similarity of cellular subunits comprising plant and animal tissues, promoting the perception of a biological unity that transcends the major kingdoms. Studies of plant development have largely been carried out in the shadow of animal developmental biology, im-
211 citations
TL;DR: This review will summarize the major historical discoveries and theories that tackled the existence and structure of membranes and will analyze how these theories impacted the understanding of the cell.
Abstract: All modern cells are bounded by cell membranes best described by the fluid mosaic model. This statement is so widely accepted by biologists that little attention is generally given to the theoretical importance of cell membranes in describing the cell. This has not always been the case. When the Cell Theory was first formulated in the XIXth century, almost nothing was known about the cell membranes. It was not until well into the XXth century that the existence of the plasma membrane was broadly accepted and, even then, the fluid mosaic model did not prevail until the 1970s. How were the cell boundaries considered between the articulation of the Cell Theory around 1839 and the formulation of the fluid mosaic model that has described the cell membranes since 1972? In this review I will summarize the major historical discoveries and theories that tackled the existence and structure of membranes and I will analyze how these theories impacted the understanding of the cell. Apart from its purely historical relevance, this account can provide a starting point for considering the theoretical significance of membranes to the definition of the cell and could have implications for research on early life. This article was reviewed by Dr. Etienne Joly, Dr. Eugene V. Koonin and Dr. Armen Mulkidjanian.
186 citations
108 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 1 |
| 2020 | 1 |
| 2019 | 2 |
| 2018 | 2 |
| 2017 | 3 |
| 2016 | 5 |