Topic
Bronchiolitis
About: Bronchiolitis is a research topic. Over the lifetime, 4857 publications have been published within this topic receiving 156803 citations. The topic is also known as: Wheezy Bronchitis.
Papers published on a yearly basis
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Papers
TL;DR: Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years.
Abstract: From 28 young children in the Netherlands, we isolated a paramyxovirus that was identified as a tentative new member of the Metapneumovirus genus based on virological data, sequence homology and gene constellation. Previously, avian pneumovirus was the sole member of this recently assigned genus, hence the provisional name for the newly discovered virus: human metapneumovirus. The clinical symptoms of the children from whom the virus was isolated were similar to those caused by human respiratory syncytial virus infection, ranging from upper respiratory tract disease to severe bronchiolitis and pneumonia. Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years.
2,170 citations
1,971 citations
TL;DR: RSV bronchiolitis in infancy severe enough to cause hospitalization was highly associatied with the development of asthma and allergic sensitization up to age 7(1)/ (2).
Abstract: We previously reported an increased risk for bronchial obstructive disease and allergic sensitization up to age 3 in 47 children hospitalized with a respiratory syncytial virus (RSV) bronchiolitis in infancy compared with 93 matched control subjects recruited during infancy. The aims of the present study were to evaluate the occurrences of bronchial obstructive disease and allergic sensitization in these children at age 71/ 2. All 140 children reported for the follow-up, which included physical examination, skin prick tests, and serum IgE tests for common food and inhaled allergens. The cumulative prevalence of asthma was 30% in the RSV group and 3% in the control group (p < 0.001), and the cumulative prevalence of “any wheezing” was 68% and 34%, respectively (p < 0.001). Asthma during the year prior to follow-up was seen in 23% of the RSV children and 2% in the control subjects (p < 0.001). Allergic sensitization was found in 41% of the RSV children and 22% of the control subjects (p = 0.039). Multivaria...
1,188 citations
1 Jan 1976
TL;DR: In all geographic areas it is now clear that RSV is the major cause of bronchiolitis and pneumonia in infants and young children, and there are many pressing questions concerning the pathogenesis of serious life-threatening disease of the lower respiratory tract produced by this virus during early infancy.
Abstract: Respiratory syncytial virus (RSV) was first isolated from a chimpanzee with common-cold-like illness.(53a) Shortly thereafter, the virus was recovered from young children with severe lower respiratory tract disease in Baltimore. (11,16) Since its initial isolation from infants with respiratory disease almost 20 yr ago, RSV has emerged as the major lower respiratory tract pathogen of infancy and early childhood throughout the world. (3,15,16,69) In all geographic areas it is now clear that RSV is the major cause of bronchiolitis and pneumonia in infants and young children. RSV presents a special challenge to the epidemiologist since this virus exhibits a pattern of infection and disease unlike that of any of the other known respiratory tract viral pathogens. Unanswered are many pressing questions concerning the pathogenesis of serious life-threatening disease of the lower respiratory tract produced by this virus during early infancy.
1,164 citations
TL;DR: Respiratory syncytial virus is the most important cause of lower respiratory tract infection in outpatients, as well as the major viral cause of nosocomial illness in pediatric inpatients.
Abstract: RSV is now understood to be the most significant viral respiratory pathogen of infants and is capable of causing both bronchiolitis and pneumonia. It is a particular risk to hospitalized infants as the virus is easily spread through close contact. The most vulnerable infants are those who suffer with either congenital heart disease or bronchopulmonary dysplasia who easily fall prey to pulmonary complications of infection. Strict environmental control and the use of protective clothing and eyewear should be implemented to decrease the nosocomial spread of RSV. Available diagnostic studies include viral isolation, fluorescent antibody stains, and enzyme immunoassays. Treatment of the disease is usually supportive but hospitalized patients frequently benefit from aerosolized ribavirin therapy. Hopefully, current vaccine trials will be successful and this pathogen will not only be treatable but will also be preventable.
1,010 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2026 | 3 |
| 2025 | 187 |
| 2024 | 327 |
| 2023 | 373 |
| 2022 | 680 |
| 2021 | 265 |