TL;DR: In this paper, a small Li6I(Eu) scintillator placed at the center of polyethylene moderating spheres with sizes ranging from 2 to 12 inches in diameter was used for detecting neutrons.
TL;DR: In this paper, ground-based measurements of the cosmic-ray induced neutron flux and its energy distribution have been made at several locations across the United States using an extended energy Bonner sphere spectrometer.
Abstract: New ground-based measurements of the cosmic-ray induced neutron flux and its energy distribution have been made at several locations across the United States using an extended-energy Bonner sphere spectrometer. The data cover over twelve decades of neutron energy, from meV to GeV. An expression to scale the flux to other locations has been developed from a fit to the altitude dependence of our measurements and an expression from the literature for the geomagnetic and solar-activity dependence of neutron monitor rates. In addition, an analytic expression is provided which fits the neutron spectrum above about 0.4 MeV. The neutron flux is important for estimating the soft-error rate in computer memories and recent computer logic devices.
TL;DR: The measurements and simulations conclude that the dose deposited by secondary neutrons during proton radiotherapy using the spot scanning technique can be neglected in the treatment region.
Abstract: Purpose: During proton radiotherapy, secondary neutrons are produced by nuclear interactions in the material in the beam line before and after entering the patient. The dose equivalent deposited by these neutrons is usually not considered in routine treatment planning. In this study, we estimated the neutron dose in patients from a spot scanning beam line by performing measurements and Monte Carlo simulations. Methods and Materials: Measurements of the secondary neutron dose were performed during irradiation of a water phantom with 177-MeV protons using a Bonner sphere and CR39 etch detectors. Additionally, Monte Carlo simulations were performed using the FLUKA code. Results: A comparison of our measurements with measurements taken at a beam line using the scatter foil technique shows a dose advantage of at least 10 for the spot scanning technique. In the region of the Bragg peak, the neutron dose equivalent can reach for a medium-sized target volume approximately 1% of the treatment dose. Neutron doses expected in healthy tissues of the patient (in the not-treated volume) are for large and medium target volumes, approximately 0.004 Sv and 0.002 Sv per treatment Gy, respectively. Conclusions: We conclude from the measurements and simulations that the dose deposited by secondary neutrons during proton radiotherapy using the spot scanning technique can be neglected in the treatment region. In the healthy tissue, the dose coming from neutrons (0.002 Sv per treatment Gy) is approximately a factor of two larger than during photon treatment (0.001 Sv). These contributions to the integral dose from neutrons are still very low when compared to the dose sparing that can be achieved by using a proton beam instead of photons.
TL;DR: The basic characteristics of Bonner sphere spectrometry systems are first described, followed by a review of the different types of system which have been built, and of how their response functions have been determined.
Abstract: The basic characteristics of Bonner sphere spectrometry systems are first described, followed by a review of the different types of system which have been built, and of how their response functions have been determined. Spectrum unfolding and recent developments are covered briefly. The practical considerations for users are emphasised wherever possible, and the advantages, disadvantages, and problems of using this spectrometer are discussed.
TL;DR: Experiments reveal that H / D varies significantly with the treatment technique, e.g., patient orientation, proton beam energy, and range-modulation.
Abstract: Measurements of neutron dose equivalent values and neutron spectral fluences close to but outside of the therapeutic proton radiation field are presented. The neutron spectral fluences were determined at five locations with Bonner sphere measurements and established by unfolding techniques. More than 50 additional neutron dose equivalent values were measured with LiI and BF 3 thermal neutron detectors surrounded by a 25 cm polyethylene moderating sphere. For a large-field treatment, typical values of neutron dose equivalent per therapeutic proton absorbed dose, H / D , at 50 cm distance from isocenter, range from 1 mSv/Gy (at 0° with respect to the proton beam axis) to 5 mSv/Gy (at 90°). Experiments reveal that H / D varies significantly with the treatment technique, e.g., patient orientation, proton beam energy, and range-modulation. The relative uncertainty in H / D values is approximately 40% (one standard deviation).