Bladder Obstruction

Abstract: The case of two female patients with de novo terminal deletion of the long arm of chromosome 10, one with del(10)(q26.2) and the other with del(10)(q26.3), is reported. Both presented with megabladder associated with urinary tract abnormalities. The case of four similar patients has been previously reported with bladder dilatation secondary to urinary obstruction. These new cases highlight the possible involvement of the bladder and the urethra in the syndrome of chromosome 10q terminal deletion, suggesting a careful renal and urinary tract evaluation in such situations. Moreover, the possibility of monosomy 10qter syndrome should be borne in mind in the case of prenatal diagnosis of apparently isolated bladder obstruction, especially in females.

Abstract: The activity of the wide, non-refluxing ureter in children was studied by intraluminal pressure measurement and perfusion. Some patients were examined by electroureterography. In order to avoid obstruction in the terminal part of the ureter, catheters were introduced into the ureter by puncture during operation. The ureter was perfused via the catheters and the reactions to different flows and bladder pressures were studied. Eight measurements were performed on patients without previous bladder obstruction and 4 on patients with such previous obstruction. Both categories included patients in whom no intraureteric obstruction to flow was observed. In other cases ureteric stasis was present, either independent of the degree of filling of the bladder or only when the bladder was filling. All ureters showed contractility. The importance of the findings for investigation and therapy in these rare cases is discussed.