Topic
Bithionol
About: Bithionol is a research topic. Over the lifetime, 103 publications have been published within this topic receiving 755 citations. The topic is also known as: Bithionol sulfide & Bis(3,5-dichloro-2-hydroxyphenyl) sulfide.
Papers published on a yearly basis
Papers
TL;DR: Bithionol effectively reduces bacterial burdens in a mouse model of chronic deep-seated MRSA infection and shows that the activity of membrane-active compounds against MRSA persisters positively correlates with their ability to increase membrane fluidity, thereby establishing an accurate biophysical indicator for estimating antipersister potency.
Abstract: Treatment of Staphylococcus aureus infections is complicated by the development of antibiotic tolerance, a consequence of the ability of S. aureus to enter into a nongrowing, dormant state in which the organisms are referred to as persisters. We report that the clinically approved anthelmintic agent bithionol kills methicillin-resistant S. aureus (MRSA) persister cells, which correlates with its ability to disrupt the integrity of Gram-positive bacterial membranes. Critically, bithionol exhibits significant selectivity for bacterial compared with mammalian cell membranes. All-atom molecular dynamics (MD) simulations demonstrate that the selectivity of bithionol for bacterial membranes correlates with its ability to penetrate and embed in bacterial-mimic lipid bilayers, but not in cholesterol-rich mammalian-mimic lipid bilayers. In addition to causing rapid membrane permeabilization, the insertion of bithionol increases membrane fluidity. By using bithionol and nTZDpa (another membrane-active antimicrobial agent), as well as analogs of these compounds, we show that the activity of membrane-active compounds against MRSA persisters positively correlates with their ability to increase membrane fluidity, thereby establishing an accurate biophysical indicator for estimating antipersister potency. Finally, we demonstrate that, in combination with gentamicin, bithionol effectively reduces bacterial burdens in a mouse model of chronic deep-seated MRSA infection. This work highlights the potential repurposing of bithionol as an antipersister therapeutic agent.
156 citations
TL;DR: The number of M. sebastis in groups fed experimental diets supplemented with mebendazole or bithionol was significantly lower than that from the control group, and the number of parasites on the gills of infected fish was significantly reduced.
62 citations
Journal Article•
TL;DR: In this paper, the clinical and computerized tomographic findings of 10 patients diagnosed with fasciola hepatica are summarized, including abdominal pain, fever, eosinophilia and abnormal liver function tests were the most commonly encountered symptoms and signs.
Abstract: Background/aims Fasciola hepatica is the cause of liver infection, fascioliasis. Although rare, it is still a problem even in developed countries. In this study, the clinical and computerized tomographic findings of 10 patients diagnosed with fascioliasis are summarized. Methods The medical records of the patients with fascioliasis were retrospectively examined. Clinical, laboratory findings and computerized tomographic results were recorded. Results Abdominal pain, fever, eosinophilia and abnormal liver function tests were the most commonly encountered symptoms and signs. One patient was human immunodeficiency virus -positive with active tuberculosis. Serologic test for fasciola hepatica was positive in all patients. Nodular masses without prominent enhancement, and branching low-attenuated tubular lesions were the most commonly seen tomographic findings and were supportive for the diagnosis. All except the HIV-positive patient received bithionol therapy; six patients responded well, two lost contact with the clinic and one patient who was unresponsive to bithionol therapy received triclabendazole. During follow-up of the six patients who responded, all the clinical and radiological findings regressed. Conclusion In any patient with peripheral eosinophilia, abdominal pain and elevated liver enzymes, especially when CT reveals tubular and nodular hypodense lesions particularly in subcapsular area, F. hepatica infection should be considered. Either triclabendazole or bithionol can be used effectively for the treatment.
61 citations
TL;DR: Various anthelmintics belonging to different pharmacological groups were tested and compared for their in vivo and in vitro activity on a natural infection of Oncorhynchus mykiss by Gyrodactylus, probably G. salaris.
Abstract: Various anthelmintics belonging to different pharmacological groups (ivermectin, clorsulon, closantel, netobimin, febantel, praziquantel, niclofolan, bithionol, trichlorfon, levamisole hydrochloride, piperazine citrate and dihydrochloride, nitroscanate), all of proven efficacy against certain helminths, were tested and compared for their in vivo and in vitro activity on a natural infection of Oncorhynchus mykiss by Gyrodactylus, probably G. salaris. The trout were also observed for signs of toxic reaction to the drugs. Complete efficacy (100 % reduction) with no toxic effects was achieved only by bithionol (20 mg I-') and nitroscanate (0.07 mg 1-l).
57 citations
TL;DR: It is concluded that bithionol is the drug of choice for both acute and chronic fascioliasis, and its oral administration may allow treatment of fasCIoliasis in outpatients who do not have serious symptoms.
55 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2019 | 1 |
| 2018 | 1 |
| 2013 | 1 |
| 2010 | 1 |
| 2009 | 2 |
| 2008 | 1 |