Bamethan

Abstract: A method for treatment of epilepsy and cerebral concussion in mammals by administration of a vasodilator in an effective amount, the vasodilator being bamethan, derivatives thereof, bamethan sulfate, derivatives thereof, 1-epinephrine derivatives having a terminal alkyl substitutent attached to nitrogen and containing at least three carbon atoms, and mixtures thereof. The frequency of epileptic seizures in mammalian patients is substantially reduced by this treatment.

Abstract: In a previous experiment, the pressor action of propranolol was observed in the spinal rat in which the β-receptor vascular tone was induced by infusions of β-adrenergic stimulating agents. This pressor action is considered to be due to the blockade of the β-adrenoceptive vasodilator tone provided by β-stimulants in the peripheral vessel. In this experiment, the pressor action of propranolol was used to investigate the mechanism of the vasodilator action of some vasodilators. Nylidrin, isoxsuprine, bamethan, acetylcholine and papaverine were used as vasodilators. Propranolol produced a pressor action in the spinal rat during infusions of the mixture of nylidrin, isoxsuprine or bamethan and vasopressin, but not during infusions of the mixture of papaverine or acetylcholine and vasopressin. This observation suggests that nylidrin, isoxsuprine and bamethan caused vasodilation through stimulation of β-vascular receptors. This method could be used to ascertian the role of β-receptor activation as a mechanism for the vasodilator action of some drugs.