TL;DR: Since the Aschoff cell appears to evolve from the Anitschkow cell, the mature Aschoffs body may be regarded as a unique granuloma and this hypothesis suggests newer approaches to the study of the AsChoff body in rheumatic heart disease.
TL;DR: Intense consistent reactivity with several histiocytic markers affirms the genesis of these cells from macrophages/histiocytes and not muscle cells; a controversy which must be laid to rest!
TL;DR: The most specific lesion of rheumatic disease is the Aschoff nodule, which has a faintly basophilic cytoplasm and a large vesicular nucleus with a prominent chromatin mass in the center.
TL;DR: In acute rheumatic fever, various types of myocardial degeneration and subsequent transformation of the damaged muscle fibers into a variety of cells, classified and unclassified, are described from microscopic examination of autopsy specimens to suggest three different pathways for cytogenesis of Aschoff cells from altered muscle fibers.