Abstract: Cancer is a large group of disorders characterized by uncontrolled cellular proliferation. It is one of the most devastating diseases all over the world. Recently, there is an increased interest in the clinical use of natural products as a safe, efficient, and economic therapeutic alternative. Honey bee products therapy, apitherapy, was used to control various diseases including cancer. In this study, samples of honey, venom and propolis were collected from different Egyptian localities with different techniques and tested by MTT cell-based assay against liver (HePG2), breast (MCF-7), and colorectal (Caco-2) cancer cell lines. The results showed that, Italian dissected method-bee venom was the most active among all the tested samples against Hep-G2 (93.92%), Caco-2 (93.92%) and MCF-7 (90.17%). However, Libyan propolis proved to be most active among all tested propolis samples. On the other hand, all tested honey samples showed non-remarkable activities except Asyut-clover honey (49.84% against Caco-2 cell line).

Abstract: Antibiotic resistance is one of the world’s most pressing health problems in 21st century. Multi Drug Resistance (MDR) is a phenomenon where the microorganism develops resistance against more than one drug. MDR typhoid is one such emerging problem. This calls for some alternative drugs or use of some compounds alone or in combination with drugs against typhoid. Apitherapy provide us the cure for this. In apitherapy, the honey bee and its hive products are used for the treatment for various ailments. In the present study, a honey bee product i.e. propolis which act as a strong antibacterial is combined with standard antibiotic i.e. cefixime against Salmonella . The time kill analysis and results of checkerboard method confirmed when propolis and cefixime were used in combination, synergy was observed.

Abstract: Introduction. The work presents review of the data literature, which indicate the prospects of creation new highly efficient drugs for the treatment of chronic prostatitis and prostate gland adenoma based bioactive standardized substances of bee products, including powdered honey (PH), propolis phenolic hydrophobic drug (PPHD) and bee pollen (BP). Materials and methods. Results of discussion of preclinical pharmacological studies of standardized substances of bee products composition – PH, PPHD and BP for the treatment of specified pathology is given in the experimental part. Results. It was found that the most pronounced anti-inflammatory effect on the level 40 % the mixture of APIs (PH, PPHD and BP) detects at a dose of 100 mg/kg in relation to the reference drug – trianom capsules in doses of 100 and 130 mg/kg. Conclusions. Usage of bee products is grounded in creation of the new drug on their basis in the form of standardized substances of bee products composition –PH, PPHD and BP for chronic prostatitis and prostate gland adenoma. It was found that the most pronounced anti-inflammatory effect on 40 % the mixture of APIs (PH, PPHD and BP) detects at a dose of 100 mg/kg. It was established that the composition of standard substances of bee products – PH, PPHD and BP at a dose of 100 mg/kg shows a more pronounced specific pharmacological effect in comparison to the reference product – trianom capsules at doses of 100 and 130 mg/kg, which positively affect the course of the pilot prostatitis in male rats caused by dichloroethyl.

Abstract: Varieties of natural products have been studied as natural therapeutic and preventive agents in the development countries. Honey is commonly used for both food stuffs and treatment of many diseases. The mono floral hayit honey has aphrodisiac effect with a nice aromatic leaves and its leaves are used as spices. This natural product obtained the hayit plan (Vitex agnus-castus L.) have effects on estrogen levels. The basis of effect mechanism is dopaminergic properties of Vitex agnuscastus L. The hayit plant which can be used as an alternative to synthetic hormone therapy and has the potential to regulate the pituitary by affecting directly on the hormonal imbalance is also used for production of monofloral honey by honey bees. This product is been used in therapy of various gynecological problems in women depending on the data obtained from apitherapy field (treatment with bee products) of natural bee products monofloral with antioxidant capacity of components of Vitex agnus-castus in the bee products which will be examined by in vitro and in vivo assays will be support.

Abstract: Honey is an ancient remedy for its medicinal application, as a treatment for burns, ulcers, and wound healing. Honey is mainly composed of carbohydrates, enzymes, amino acids, lipids, vitamins, minerals, and aromatic substances. Flavonoids and phenolic acids are the most important compounds in honey that display a wide range of biological activities. Depending on its origin, climate, and honeybee species, honey has different colors, compositions, aromas, and flavors. Therefore, various types of honey have different therapeutic effects. Honey affects the wound healing processes by several mechanisms. It rapidly removes bacteria from the colonized and infected wounds due to its hydrogen peroxide, high osmolality, acidity, non-peroxide factors, nitric oxide, and phenols. As a dressing on wounds, honey promotes autolytic debridement, stimulates anti-inflammatory activities, and enhances fibroplasia and angiogenesis in the wound bed. This chapter aims to review the medicinal properties of honey and describe its mechanism of action on wound healing.

Abstract: Objective Honey is one of the oldest known medicines. Its medical and therapeutic importance has been recently rediscovered. Honey is an effective treatment for infected wounds and ulcers. The aim of this study was to determine the effect of honey as a topical therapy for intraoral wound healing in rats. Materials and methods Thirty-two male rats were divided into experimental and control groups (consisting of 16 rats, 4 animals in each group). A 2-mm mucosal defect was made to the depth of the periosteum using punch biopsy. Honey was applied to the wound every day, and the ulcer size was measured daily. On days 2, 4, 6, and 8, four rats were euthanized from each group (experimental and control groups), and tissues were histopathologically evaluated. Healing processes were studied as follows: the size of ulcer, inflammatory response, reepithelialization, and granulation tissue formation. Results The mean rank of wound size was significantly reduced in the honey group (2.50), as compared to the control group (6.50). Reepithelialization and granulation tissue formation mean rank were significantly higher in the honey group (6.50) than in the control group (2.50). Inflammation mean rank was statistically lower in the honey group (2.63) compared with the control group (6.38). Conclusion Honey was shown to have a beneficial effect on the healing of oral ulcers in rats in this model. Further research may shed light on the effects of honey on different types of ulcers in humans.