TL;DR: TRPV4 is a functional temperature-sensing channel in native endothelium, that is likely involved in temperature-dependent Ca2+ signaling, and the failure to activate TRPV 4 channels by heat in inside-out patches, which responded to 4αPDD, may indicate that heat activation depends on the presence of an endogenous ligand, which is missing in inside/out patches.
TL;DR: A new ankyrin gene is characterized, expressed in brain and other tissues, that is subject to extensive tissue-specific alternative mRNA processing and has a predicted globular head domain, with membrane- and spectrin-binding activities, as well as an extended "tail" domain.
TL;DR: In this paper, the authors present biochemical evidence that the cytoplasmic domains of neurofascin, L1, NrCAM, NgCAM and neuroglian are associated directly with ankyrins, a family of spectrin-binding proteins located on the membrane domains.