Anisic acid

Abstract: The inhibition of mushroom tyrosinase by Pulsatilla cernua root-derived materials was evaluated. The bioactive components of Pulsatilla cernua root were characterized by spectroscopic analyses as 3,4-dihydroxycinnamic acid and 4-hydroxy-3-methoxycinnamic acid, which exhibited potent antityrosinase activity. The ID50 values of 3,4-dihydroxycinnamic acid and 4-hydroxy-3-methoxycinnamic acid were 0.97 and 0.33 mM, respectively. The compounds isolated from Pulsatilla cernua roots exhibited noncompetitive inhibition against oxidation of L-DOPA by mushroom tyrosinase. This activity was compared with that of three cinnamic acid derivatives and four well-known tyrosinase inhibitors. The ID50 of 4-hydroxy-3-methoxycinnamic acid exhibited superior activity relative to anisaldehyde, anisic acid, benzoic acid, benzaldehyde, cinnamic acid, and cinnamaldehyde; but antityrosinase inhibitors and cinnamic acid derivatives, except for cinnamyl alcohol, were slightly more effective than 3,4-dihydroxycinnamic acid. In the ca...

Abstract: A universal method to separate and quantify 13 phenolic acids (gallic acid, chlorogenic acid, gentsic acid, vanillic acid, caffeic acid, syringic acid, sinapic acid, p-coumaric acid, ferulic acid, anisic acid, rosmarinic acid, salicylic acid, and cinnamic acid) in some compound herbal medicines was established by liquid chromatographic (HPLC). On an Agela XBP-C18 (5 μm, 4.6 mm × 150 mm) column, a multistep binary gradient elution program and a simplified sample pretreatment approach were used in the experiment. For all of the phenolic acids, detection limits ranged around 0.01 mg/L. Linear ranges of higher than 2 orders of magnitude were obtained with a correlation coefficient of 0.9991 to 1. Repeatability was 0.39−2.24% (relative standard deviation, RSD) for intraday, 1.17−3.96% (RSD) for interday, and 0.14−5.33% (RSD) for drug sample analysis. Recovery, tested by a standard addition method, ranged from 83.3% to 104.9% for various trace phenolic acids. Keywords: Phenolic acid; compound herbal medicines; ...

Abstract: Analysis of the inhibitors from allelopathic species of Parthenium hysterophorus L. revealed that sesquiterpene lactones and phenolics formed an important group of water soluble compounds involved in allelopathy. Parthenin was the major sesquiterpene lactone involved though dampsin was also found in traces. Caffeic acid, vanillic acid, ferulic acid, chlorogenic acid, and anisic acid among the phenolics and fumaric acid among the organic acids were the important constituents of the air dried parts of the plant, many of them being traced in the root exudates, leaf washings, pollen and trichome leachates. © 1980 Martinus Nijhoff Publishers.