TL;DR: These initial performance characteristics of a new solid-state single-photon γ-camera offer great promise for clinical dynamic SPECT protocols, with important implications for applications in nuclear cardiology and molecular imaging.
Abstract: This study described and validated a new solid-state single-photon γ-camera and compared it with a conventional-SPECT Anger camera. The compact new camera uses a unique method for localizing γ-photon information with a bank of 9 solid-state detector columns with tungsten collimators that rotate independently. Methods: Several phantom studies were performed comparing the new technology with conventional-SPECT technology. These included measurements of line sources and single- and dual-radionuclide studies of a torso phantom. Simulations were also performed using a cardiothoracic phantom. Furthermore, 18 patients were scanned with both the new camera and a conventional-SPECT camera. Results: The new camera had a count sensitivity that was 10 times higher than that of the conventional camera and a compensated spatial resolution that was moderately better. Dual-radionuclide studies using a phantom show the further potential of the new camera for a 2-tracer simultaneous acquisition. Two-minute clinical studies with the new camera and 11-min studies with the conventional camera qualitatively showed good-to-excellent image quality and improved myocardial edge definition for the new camera. Conclusion: These initial performance characteristics of a new solid-state single-photon γ-camera offer great promise for clinical dynamic SPECT protocols, with important implications for applications in nuclear cardiology and molecular imaging.
TL;DR: The key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts are discussed with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic.
Abstract: The development of radiation detectors capable of delivering spatial information about gamma-ray interactions was one of the key enabling technologies for nuclear medicine imaging and, eventually, single-photon emission computed tomography (SPECT). The continuous sodium iodide scintillator crystal coupled to an array of photomultiplier tubes, almost universally referred to as the Anger Camera after its inventor, has long been the dominant SPECT detector system. Nevertheless, many alternative materials and configurations have been investigated over the years. Technological advances as well as the emerging importance of specialized applications, such as cardiac and preclinical imaging, have spurred innovation such that alternatives to the Anger Camera are now part of commercial imaging systems. Increased computing power has made it practical to apply advanced signal processing and estimation schemes to make better use of the information contained in the detector signals. In this review we discuss the key performance properties of SPECT detectors and survey developments in both scintillator and semiconductor detectors and their readouts with an eye toward some of the practical issues at least in part responsible for the continuing prevalence of the Anger Camera in the clinic.
TL;DR: P positron-computed section imaging has a tenfold increase in sensitivity over multiple-view imaging with the scintillation camera, which gives multiple sections but requires camera or patient rotation.
Abstract: Computed transverse section emission tomography using /sup 99m/Tc with the Anger camera is compared to positron annihilation coincident detection using a ring of crystals and /sup 68/Ga. The single-photon system has a line spread function (LSF) of 9 mm full width at half maximum (FWHM) at the collimator and gives a transverse section reconstruction LSF of 11 mm FWHM with 144 views. The positron ring has a LSF of 6 mm at the center with a transverse section reconstruction LSF of 7.5 mm FWHM. Positron-computed section imaging has a tenfold increase in sensitivity over multiple-view imaging with the scintillation camera, which gives multiple sections but requires camera or patient rotation.
TL;DR: In this paper, a coded aperture camera was designed for high-resolution (1.66-mm) imaging of low energy (140 keV) gamma-ray emitters with a conventional camera.
Abstract: Coded apertures have been investigated in the past for their promise of an improved signal-to-noise ratio (SNR) over pinhole and collimator systems. We describe a coded aperture camera designed for high-resolution (1.66-mm) imaging of low energy (140 keV) gamma-ray emitters with a conventional Anger camera. The aperture pattern was chosen to maximize the SNR and to allow a simple implementation of a new near-field artifact compensation technique based on the use of an antisymmetric array. Experimental results show that coded aperture imaging can produce good quality high-resolution planar images with high SNR while keeping exposure times and injected doses at reasonable levels.
TL;DR: A Monte Carlo simulation of photon transport which includes collimator scatter is developed and Comparisons of measured and simulated PSFs demonstrate the validity of the model and the significance of collimators scatter in the degradation of image quality.
Abstract: The geometric component of the point spread function (PSF) of a gamma camera collimator can be determined analytically, and the penetration component can be calculated readily by numerical ray-tracing. A Monte Carlo simulation of photon transport which includes collimator scatter is developed. The simulation was implemented with an array processor which propagates up to 1024 photons in parallel, allowing accurate estimates of the total radial PSF in less than a day. The simulation was tested by imaging monoenergetic point sources of Tc-99m, Cr-51, and Sr-85 (140, 320, and 514 keV, respectively) on a General Electric Star Cam with low-energy, general-purpose, and medium-energy collimators. Comparisons of measured and simulated PSFs demonstrate the validity of the model and the significance of collimator scatter in the degradation of image quality. >