Topic
Anal Margin
About: Anal Margin is a research topic. Over the lifetime, 187 publications have been published within this topic receiving 4801 citations.
Papers published on a yearly basis
Papers
TL;DR: Surgery has largely supplanted radiation therapy as the primary treatment modality for anal cancer, especially when there is a chance for cure, and these lesions, which lie in close relationship to the dentate line, are neoplasms with rapid growth characteristics.
Abstract: IN COMPARISON with adenocarcinoma of the rectum, anal cancer is uncommon. 2 According to Morson, a one squamous-cell cancer is seen for every 28 rectal adenocarcinomas, an incidence of about .'4.5 per cent. As a consequence, individual experience with anal cancer is limited. Fortunately, several recent collective reviews provide guidelines for treatment. 4, s Surgery has largely supplanted radiation therapy as the primary treatment modality for anal cancer, especially when there is a chance for cure. Local excision is usually done for cancer of the anal margin, while resection of the rectum is the preferred treatment for cancer of the anal canal. Resuhs of surgical treatment o~ cancer of the anal margin are good, since the lesions are usually well differentiated, but this is not the case with cancer of the anal canal. These lesions, which lie in close relationship to the dentate line, are neoplasms with rapid growth characteristics. They are highly anaplastic squamous cancers with various cell types sometimes described in terms such as "transitional," "basaloid," or "cloacogenic." These tunaors generally have a poor prognosis.a
1,096 citations
Book•
1 Jan 1976
TL;DR: The histological classification of Intestinal Tumours led to an understanding of the role ofestine in the development of tumours and the role that theestine plays in the progression of these tumours.
Abstract: Introduction Histological Classification of Intestinal Tumours Small Intestine Appendix Large Intestine Anal Canal Anal Margin Definitions and Explanatory Notes Small Intestine Appendix Large Intestine Anal Canal Anal Margin Subject Index
736 citations
TL;DR: In this article, the authors provide guidelines which can assist medical, radiation and surgical oncologists in the practical management of this unusual cancer, which is strongly associated with human papilloma virus (HPV, types 16-18) infection.
Abstract: Squamous cell carcinoma of the anus (SCCA) is a rare cancer but its incidence is increasing throughout the world, and is particularly high in the human immunodeficiency virus positive (HIV+) population. A multidisciplinary approach is mandatory (involving radiation therapists, medical oncologists, surgeons, radiologists and pathologists). SCCA usually spreads in a loco-regional manner within and outside the anal canal. Lymph node involvement at diagnosis is observed in 30%–40% of cases while systemic spread is uncommon with distant extrapelvic metastases recorded in 5%–8% at onset, and rates of metastatic progression after primary treatment between 10 and 20%. SCCA is strongly associated with human papilloma virus (HPV, types 16–18) infection. The primary aim of treatment is to achieve cure with loco-regional control and preservation of anal function, with the best possible quality of life. Treatment dramatically differs from adenocarcinomas of the lower rectum. Combinations of 5FU-based chemoradiation and other cytotoxic agents (mitomycin C) have been established as the standard of care, leading to complete tumour regression in 80%–90% of patients with locoregional failures in the region of 15%. There is an accepted role for surgical salvage. Assessment and treatment should be carried out in specialised centres treating a high number of patients as early as possible in the clinical diagnosis. To date, the limited evidence from only 6 randomised trials [1,2,3,4,5,6,7] , the rarity of the cancer, and the different behaviour/natural history depending on the predominant site of origin, (the anal margin, anal canal or above the dentate line) provide scanty direction for any individual oncologist. Here we aim to provide guidelines which can assist medical, radiation and surgical oncologists in the practical management of this unusual cancer.
622 citations
TL;DR: In this paper, the authors provide guidelines which can assist medical, radiation and surgical oncologists in the practical management of this unusual cancer, which is strongly associated with human papilloma virus (HPV) infection.
234 citations
TL;DR: Epidermoid cancer of the anal margin should be distinguished from that in the canal because of its different clinical and pathologic characteristics, the suitability of local excision for its treatment, and its better overall prognosis.
Abstract: Epidermoid cancer of the anal margin should be distinguished from that in the canal because of its different clinical and pathologic characteristics, the suitability of local excision for its treatment, and its better overall prognosis. In addition, margin cancer rarely metastasises to visceral sites. Forty-eight patients with epidermoid cancer of the anal margin were reviewed. Two refused treatment, 4 had palliative therapy for advanced, inoperable disease, 31 had local excision, and 11 were treated by abdominoperineal resection. Local excision provided satisfactory results with a corrected 5 year survival of 88 percent, although locoregional recurrence developed in 46 percent of these patients during follow-up. A second local excision or inguinal lymphadenectomy provided good results in the patients with recurrence. Abdominoperineal resection did not provide better overall survival figures.
131 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2022 | 1 |
| 2021 | 2 |
| 2020 | 10 |
| 2019 | 5 |
| 2018 | 5 |
| 2017 | 9 |