Topic
Ampulla
About: Ampulla is a research topic. Over the lifetime, 554 publications have been published within this topic receiving 7478 citations.
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Papers
TL;DR: In this study the experiences with carcinomas of the pancreas, ampulla of Vater, terminal comma bile duct, and duodenum found in a series of 3,610 patients collected from 57 major Japanese institutions was compiled over a 26 year period.
Abstract: In this study the experiences with carcinomas of the pancreas, ampulla of Vater, terminal comma bile duct, and duodenum found in a series of 3,610 patients collected from 57 major Japanese institutions was compiled over a 26 year period. The results were analyzed as to the success of resectional and palliative surgery for the various lesions. The most common lesion was carcinoma of the head of the pancreas. Unifortunately, only 18.3% of these patients were resectable with a 25.3% mortality. Carcinoma of the body and the tail was the second most frequent lesion, and it also exhibited a low resection rate. Carcinomas of the ampulla and the terminal common bile duct and duodenal regions were the most favorable for resection; usually pancreatoduodenectomy with an overall mortality of 20.8%. As a result of the large number of pancreatectomies performed, there was also a large number of postoperative complications, the most frequent being leakage at an anastomotic line. Hemorrhage also occurred frequently. Distal pancreatectomies were reserved for carcinoma of the body and the tail of the pancreas, and the most common postoperative complication of this procedure was hemorrhage. There were only 45 total pancreatectomies among the 973 resections being performed most frequently in patients with carcinoma of the head of the pancreas. Again, the most frequent postoperative complication was hemorrhage, followed by anastomotic leakage. The long term survivals following resection for these lesions were each poor. The best mean survival time was 22.7 months for carcinoma of the ampulla of Vater. Patients having resections for carcinoma of the head of the pancreas had a mean survival time of 12.3 months. At 5 years there were few survivors and most of them were patients who had undergone resections for carcinoma of the ampulla of Vater.
238 citations
TL;DR: Preovulatory temperature differences are thought primarily to reflect the extent and activity of the vascular and lymphatic beds in the oviduct tissues and, together with specific chemical microenvironments, may facilitate the relatively prolonged period of sperm storage in the distal portion of the isthmus.
Abstract: Fine thermistor probes positioned in each end of the same oviduct and connected to the same scale were used to measure temperature gradients in the lumen before and after spontaneous ovulation in normally-cyclic gilts. Readings were taken after full surgical closure of a mid-ventral incision and a subsequent period of stabilization, but whilst animals remained under general anaesthesia. A small but consistent difference in temperature was recorded between the proximal ampulla and distal isthmus of the same oviduct in each of 20 preovulatory gilts. In 10 of these animals that had not mated, the isthmus was a mean of 0.43 degree C cooler than the ampulla (range 0.2-0.7 degree C) whereas in 10 mated animals the isthmus was 0.69 degree C cooler (range 0.2-1.6 degree C); 3 animals in the latter group had within-oviduct differences of greater than or equal to 1 degrees C. By contrast, in 12 animals that had recently ovulated, the isthmus was a mean of only 0.1 degree C cooler than the ampulla; there was no measurable temperature gradient in 3 of the animals, whilst the isthmus was 0.1 degree C warmer in 2 animals. The preovulatory temperature differences are thought primarily to reflect the extent and activity of the vascular and lymphatic beds in the oviduct tissues and, together with specific chemical microenvironments, may facilitate the relatively prolonged period of sperm storage in the distal portion of the isthmus.
139 citations
Journal Article•
TL;DR: The data suggest that in ampullary neoplasia p53 mutations are common abnormalities associated with the transformation of adenomas and low-grade cancers into morphologically high-grade carcinomas, and Ki-ras mutations are relatively less frequent and might be restricted to tumors originating from the bile duct component of the ampulla.
Abstract: Eleven tumors of the ampulla of Vater (5 stage IV and 2 stage II adenocarcinomas, 1 stage II papillary carcinoma, 1 neuroendocrine carcinoma, and 2 adenomas, one with foci of carcinoma) were examined for Ki-ras and p53 gene mutations by single-strand conformation polymorphism analysis and direct sequencing of polymerase chain reaction-amplified DNA fragments. Ki-ras mutations were found in one adenocarcinoma and in the adenoma with foci of carcinoma, both involving mainly the intraduodenal bile duct component of the ampulla. Seven cases showed p53 gene mutations: four advanced-stage adenocarcinomas, the papillary carcinoma, the neuroendocrine carcinoma, and the adenoma with foci of carcinoma. Nuclear accumulation of p53 protein was immunohistochemically detected in the morphologically high-grade areas of the five cancers harboring a p53 gene missense point mutation. The adenomas, the two frame shift-mutated cancers, and the adenomatous and low-grade cancer areas of mutated carcinomas were immunohistochemically negative. Our data suggest that in ampullary neoplasia 1) p53 mutations are common abnormalities associated with the transformation of adenomas and low-grade cancers into morphologically high-grade carcinomas, and 2) Ki-ras mutations are relatively less frequent and might be restricted to tumors originating from the bile duct component of the ampulla.
134 citations
TL;DR: Results indicate that porcine oviductal tissue synthesizes specific EAP at the time of fertilization and early cleavage-stage embryonic development, that there are differences in the type and distribution of glycoproteins from ampulla and isthmus, and that post-translational modifications occur with the addition of glucosamine, fucose, and inorganic sulfate.
Abstract: Oviductal secretory products provide a biochemical environment important for establishment of pregnancy. A previous study identified three de novo-synthesized glycoproteins by one-dimensional SDS-PAGE as well as increased incorporation of [3H]Leu into secretory protein by whole oviduct and ampulla associated with proestrus, estrus, and metestrus only. Here, our objective was to further identify and characterize oviductal secretory proteins, specifically 115,000- and 85,000-Mr estrus-associated proteins (EAP). Two-dimensional SDS-PAGE resolved the 115,000-Mr protein into two proteins of 100,000 Mr, one basic and one acidic, and the 85,000-Mr protein into 75,000- and 85,000-Mr species (pI less than 4.0). Differential secretion of proteins between ampulla and isthmus was indicated. The 100,000-, 75,000-, and 85,000-Mr proteins were synthesized by ampulla during estrus but not by isthmus nor by uterine endometrium. De novo-synthesized EAP were labeled with glucosamine, Leu, and Met, and the 75,000-85,000-Mr proteins from ampulla and a 30,000-Mr family from isthmus were labeled with fucose. Inorganic [35S]sulfate labeled three EAP. Fractionation of culture medium by gel filtration demonstrated differences between products secreted by ampulla and isthmus and suggested that some EAP may be found as high-molecular weight forms in the native state. Results indicate that porcine oviductal tissue synthesizes specific EAP at the time of fertilization and early cleavage-stage embryonic development, that there are differences in the type and distribution of glycoproteins from ampulla and isthmus, and that post-translational modifications occur with the addition of glucosamine, fucose, and inorganic sulfate.
128 citations
TL;DR: The high male to female ratio of small bowel adenocarcinomas in blacks and non-Latino whites is confirmed, but could find no evidence of such an effect in Latinos or Asians; however, the number of cases was not large in these latter two racial-ethnic groups.
Abstract: Using pathology reports and other data from the Cancer Surveillance Program, the population-based cancer registry of Los Angeles County, we evaluated demographic characteristics and the detailed subsite distribution of adenocarcinomas of the small intestine for the period 1972-1985. The most striking finding was the great preponderance of these tumours in the duodenum, especially in comparison with other histologic types of small bowel cancers. Fifty percent of all small intestinal adenocarcinomas occurred at this location, even though the duodenum comprises just 4% of the entire length of the small bowel. Furthermore, after excluding those cases occurring in the duodenum but with indeterminate subsite, 57% of these duodenal primaries could be mapped to the 2nd portion of the duodenum, a six to seven centimeter segment containing the Ampulla of Vater. We could pinpoint the location for 48 of the 77 tumours (62%) occurring in this segment, specifically to areas adjacent to the Ampulla. We also confirmed the high male to female ratio of small bowel adenocarcinomas in blacks and non-Latino whites, but could find no evidence of such an effect in Latinos or Asians; however, the number of cases was not large in these latter two racial-ethnic groups.
125 citations
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Performance Metrics
| Year | Papers |
|---|---|
| 2026 | 1 |
| 2025 | 19 |
| 2024 | 43 |
| 2023 | 45 |
| 2022 | 125 |
| 2021 | 18 |