Showing papers on "Amorphism published in 2017"
TL;DR: In this paper, a novel Pd-based nanoporous structure composed of amorphous nanoparticles and interconnected conduits has been successfully fabricated by electrochemical dealloying of Pd32Ni48P20 metallic glass at a relatively low potential (0.85 ǫV) in sulfuric acid solution.
36 citations
TL;DR: MGST has been shown to have a significant impact on co-milled dry powder stability after storage at elevated humidity in terms of physico-chemical properties and aerosol performance.
Abstract: Context: Particle micronization for inhalation can impart surface disorder (amorphism) of crystalline structures. This can lead to stability issues upon storage at elevated humidity from recrystallization of the amorphous state, which can subsequently affect the aerosol performance of the dry powder formulation.Objective: The aim of this study was to investigate the impact of an additive, magnesium stearate (MGST), on the stability and aerosol performance of co-milled active pharmaceutical ingredient (API) with lactose.Methods: Blends of API-lactose with/without MGST were prepared and co-milled by the jet-mill apparatus. Samples were stored at 50% relative humidity (RH) and 75% RH for 1, 5, and 15 d. Analysis of changes in particle size, agglomerate structure/strength, moisture sorption, and aerosol performance were analyzed by laser diffraction, scanning electron microscopy (SEM), dynamic vapor sorption (DVS), and in-vitro aerodynamic size assessment by impaction.Results: Co-milled formulation wi...
28 citations
TL;DR: In this article, the quantum crystallographic phases of a Rydberg-dressed Bose gas loaded on a square lattice were numerically investigated using the mean-field Gross-Pitaevskii model.
Abstract: We numerically investigate the quantum crystallographic phases of a Rydberg-dressed Bose gas loaded on a square lattice by using the mean-field Gross-Pitaevskii model. For a relatively weak lattice confinement, the phases of ground state undergo amorphism, polycrystal, and polymorphism following the increase of the blockade radius, and if the confinement is stronger, a single crystal with a specific filling factor will be formed. In order to distinctively characterize these phases, the structure function is also studied. In such an anisotropic system, we show that the superfluid-fraction tensor should be a measurable quantity, and an anisotropy parameter can be defined. In addition, for such crystallographic phases, the interaction potential can manifest where the grain boundaries appear.
5 citations
Patent•
2 Feb 2017
TL;DR: The X ray powder diffraction pattern of the crystalline form of masitinib mesylate has characteristic peaks at the positions where 2theta values are 0.7+/-0.2 degrees as mentioned in this paper.
Abstract: The present invention provides a crystalline form A of masitinib mesylate, a preparation method therefor and a medical use thereof. The X ray powder diffraction pattern of the crystalline form A has characteristic peaks at the positions where 2theta values are 0.7+/-0.2 degrees, 18.2+/-0.2 degrees, and 21.1+/-0.2 degrees. The crystalline form A can be obtained by reaction and crystallization in cyclic ether, aromatic hydrocarbon and halogenated hydrocarbon organic solvents of amorphism or solvate of masitinib mesylate or a mixed solvent of amorphism or solvate of masitinib mesylate and water. Compared with crystalline form in the prior art, the hygroscopicity of crystalline form A is remarkably reduced. Therefore, it is convenient for medicaments preparation and long-term storage. The product has higher industrialized application values.
1 citations
Patent•
25 Jan 2017
TL;DR: In this paper, an amorphism of compound A benzoate, a preparation method thereof, and a medicinal composition are described. But the preparation method is not described. And the amorphisms are not described in detail.
Abstract: The invention belongs to the field of preparation of medicinal compositions, and particularly relates to an amorphism of compound A benzoate, a preparation method thereof and an amorphism-containing medicinal composition.
1 citations
TL;DR: Particle size analysis of the lyophilized formulas showed that Tween 80 was an effective nanoparticles stabilizer in contrast to Pluronic F68 and PVA which failed to prevent nanoparticles flocculation when they were used at high concentration, and the combined effects of nanonization and amorphism contributed to the improvement in solubility.
TL;DR: PLA with FCS exhibits exceptionally simultaneous enhancement in ductility, strength, and stiffness, outperforming normal PLA with increments of 728, 55, and 70% in elongation at break, strength and modulus, respectively.
Abstract: As a biobased and biodegradable polyester, polylactide (PLA) is widely applied in disposable products, biomedical devices, and textiles. Nevertheless, due to its inherent brittleness and inferior strength, simultaneously reinforcing and toughening of PLA without sacrificing its biodegradability is highly desirable. In this work, a robust assembly consisting of compact and well-ordered microfibrillar crystalline superstructure (FCS) surrounded by slightly oriented amorphism, is achieved by a combined external force field. Unlike the classic crystalline superstructures such as shish-kebabs, cylindrites, and lamellae, the newfound FCS with diameter of about 100 nm and length of several tens of micrometers is aggregated with well-aligned crystalline nanofibers. FCS can serve as discontinuous fiber to self-reinforce the amorphous PLA; more importantly, FCS can also act as rivets to pin the propagating fibrillar crazes leading to the formation of dense fibrillar crazes during stretching, which dissipates much e...