Topic
Alseroxylon
About: Alseroxylon is a research topic. Over the lifetime, 5 publications have been published within this topic receiving 45 citations. The topic is also known as: Rauwiloid & Rau-Tab.
Papers
TL;DR: This report is a comparative study of Rauwolfia in treating hypertension and has two major objectives, to compare the clinical results obtained with single, pure alkaloids of RAUwolfia serpentina and those obtained with preparations containing reserpine and rescinnamine.
Abstract: Rauwolfia has been used for many years in India for treating hypertension, nervous disorders, and as a sedative.1Since the introduction of the first Rauwolfia serpentina preparation to American clinics,* a large number of Rauwolfia derivatives have been investigated regarding effectiveness in treating arterial hypertension. A standardized alkaloidal extract (alseroxylon) was introduced into this country in 1952.4Since this time, a number of other preparations have been made available, including at least two isolated active alkaloids, reserpine6and rescinnamine.7 Although the Rauwolfia bibliography is quite large, there have been relatively few reported studies in which the efficacy of the various derivatives of Rauwolfia have been compared. This report is a comparative study of Rauwolfia in treating hypertension and has two major objectives, (1) to compare the clinical results obtained with single, pure alkaloids of Rauwolfia serpentina (e.g., reserpine and rescinnamine) and those obtained with preparations containing
17 citations
TL;DR: Preliminary observations on the continued oral administration of these Rauwolfia serpentina preparations in arterial hypertension and to compare their hypotensive effects are presented.
11 citations
TL;DR: Many recent studies have established the therapeutic effectiveness of Rauwolfia alkaloids, both in internal medicine and in neuropsychiatry, and it was not until recently that pharmacologically and clinically active alkaloid were prepared in pure forms.
Abstract: Many recent studies have established the therapeutic effectiveness of Rauwolfia alkaloids, both in internal medicine and in neuropsychiatry. As a consequence, there is great interest in the chemistry, and particularly in the pharmacodynamics, of these alkaloids. Although a chemical study of preparations made from the roots of Rauwolfia serpentina had been attempted toward the end of the 19th century, it was not until 1931 1 that the alkaloids were subdivided into the two principal groups containing the ajmaline and serpentine alkaloids, respectively. Later other extracts were made from Rauwolfia serpentina. The alseroxylon fraction was prepared in 1952. 2 In spite of the efforts of many investigators, it was not until recently that pharmacologically and clinically active alkaloids were prepared in pure forms. The first such alkaloid to be isolated was reserpine. 3 Some investigators have attributed the hypotensive action of the whole root to this single alkaloid * when used for
10 citations
TL;DR: In this paper, Rauwolfia toxicity in the treatment of hypertension is discussed. But the authors do not discuss the effects of the toxicity on the treatment itself, only its effects on the patient.
Abstract: (1958). Rauwolfia Toxicity in the Treatment of Hypertension. Postgraduate Medicine: Vol. 23, No. 1, pp. 41-48.
9 citations
TL;DR: The effectiveness of Rauwolfia serpentina drugs in the control of overt anxiety in ambulatory psychiatric patients is equal to that of a conventional treatment of anxiety, as shown in a study of matched patient groups.
Abstract: 1.
The effectiveness of Rauwolfia serpentina drugs in the control of overt anxiety in ambulatory psychiatric patients is equal to that of a conventional treatment of anxiety, as shown in a study of matched patient groups.
2.
Three forms of Rauwolfia, reserpine, alseroxylon and the whole crude root, gave the same results in the control of overt anxiety in ambulatory patients.
3.
Techniques for the clinical use of the Rauwolfia drugs are reported.
4.
A wide variety of minor toxic symptoms in the use of Rauwolfia drugs was noted and easily controlled.
5.
Depressive symptoms are not altered by Rauwolfia drugs given at the quantity and duration levels of this study.
6 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 1958 | 1 |
| 1957 | 1 |
| 1955 | 3 |