Topic
Adrenosterone
About: Adrenosterone is a research topic. Over the lifetime, 85 publications have been published within this topic receiving 1287 citations. The topic is also known as: (8S,9S,10R,13S,14S)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11,17-trione.
Papers published on a yearly basis
Papers
TL;DR: The results establish that adrenosterone is the major precursor of 11-ketotestosterone in both interrenal and testicular tissue and that the production of 11β-hydroxytestosterone by normal gonadal tissue is reported for the first time.
Abstract: The in vitro synthesis of 11-ketotestosterone and 11β-hydroxytestosterone, from adrenosterone and testosterone, by gonadal and interrenal slices and by sperm was studied. The results establish that adrenosterone is the major precursor of 11-ketotestosterone in both interrenal and testicular tissue. 11β-Hydroxytestosterone was synthesized mainly from testosterone by gonadal and interrenal tissue. The production of 11β-hydroxytestosterone by normal gonadal tissue is reported for the first time.
75 citations
TL;DR: The biosynthetic studies suggest a pathway of testosterone formation from progesterone in the testicular tissue of this fish similar to that which is reported for mammalian testes.
69 citations
TL;DR: The rates were measured at which a number of different steroids were secreted by the adrenal gland of the eviscerated and nephrectomized young pig and dog.
Abstract: 1. The rates were measured at which a number of different steroids were secreted by the adrenal gland of the eviscerated and nephrectomized young pig and dog.
2. In addition to cortisol and corticosterone the following steroids were consistently found to be present in the adrenal venous blood: pregnenolone, progesterone, 11βOH-progesterone, androstenedione, 11βOH-androstenedione and adrenosterone.
3. The sum of the latter steroids could amount to as much as 30% of the total steroid secretion.
4. A severe deficit in the blood volume increased the secretion of pregnenolone and the 17-oxo steroids in the pig.
5. α-ethyltryptamine failed to inhibit ACTH release if the animals were eviscerated and nephrectomized, or if they were anaesthetized with chloralose instead of pentobarbitone sodium.
6. The same steroids as in the adrenal venous blood were found in extracts from the adrenal glands of a number of species.
7. The amount of individual steroids present in the adrenal gland of the stressed pig and dog was compared with the rate at which each had been secreted immediately before the excision of the gland.
8. There was a positive correlation between the adrenal concentrations and the secretion rates of cortisol, the major glucocorticoid secreted by the pig and the dog.
9. In contrast, the rate at which pregnenolone was secreted did not show a consistent relationship to its concentration in the gland.
10. A storage mechanism for pregnenolone in the adrenal cortex is proposed.
51 citations
TL;DR: A method of systematic analysis by paper chromatography of metabolites formed during cortisone perfusion through rat livers is presented and the relationship of these findings to an understanding of pathways of corticosteroid metabolism in liver is briefly discussed.
49 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2020 | 1 |
| 2019 | 1 |
| 2018 | 1 |
| 2017 | 2 |
| 2016 | 1 |
| 2015 | 1 |