Topic
Adipsia
About: Adipsia is a research topic. Over the lifetime, 202 publications have been published within this topic receiving 7375 citations.
Papers published on a yearly basis
1 / 2
Papers
TL;DR: It was concluded that bilateral complete degeneration of the nigro-striatal DA pathway produces severe, long lasting adipsia and aphagia, hypoactivity, difficulties to initiate activity and loss of exploratory behaviour and curiosity.
Abstract: The functional role of the nigro-striatal dopamine (DA) system has been investigated on the basis of a recent detailed mapping of its path and a new method of lesioning the catecholamine systems selectively by intracerebral injection of 6-hydroxydopamine (6-OH-DA). The investigation was especially focused on the symptoms of adipsia, aphagia, hypokinesia and catalepsia after lateral hypothalamic lesions as such lesions may interrupt the ascending DA axons. Electrocoagulations or 6-OH-DA lesions were performed bilaterally at several sites along the DA pathway and the behavioural effects were evaluated in relation to the histochemically detected lesion of the DA pathway. It was concluded that bilateral complete degeneration of the nigro-striatal DA pathway produces severe, long lasting adipsia and aphagia, hypoactivity, difficulties to initiate activity and loss of exploratory behaviour and curiosity. Experiments with DA receptor stimulating and blocking drugs supported the lesion results. Catalepsia and somnolence were attributed to the interruption of other pathways. The results suggest an important role for the nigro-striatal DA system and the striatum in the control of behaviour. A number of symptoms earlier related to the hypothalamus may in fact be due to disturbance of the nigro-striatal DA system.
1,322 citations
TL;DR: The results are in agreement with recent reports of the anatomical and biochemical effects of intracerebral kainic acid injections and suggest that the observed effect on feeding behavior is related to the destruction of neurons in the lateral hypothalamus.
Abstract: Microinjections of the excitatory neurotoxin kainic acid into the lateral hypothalamus of rats produced a period aphagia and adipsia. Kainate-treated rats displayed transient motor effects during the first hours after the injection but did not show the persisting sensory-motor and arousal disturbances typically observed in animals with electrolytic lesions in this part of the hypothalamus. Histological examination revealed a significant reduction in the number of nerve cell bodies in the lateral hypothalamus. Silver-stained material indicated no evidence of damage to fiber systems passing through the affected region. Assays of dopamine in hypothalamus, striatum, and telencephalon did not indicate significant differences between experimental and control animals. These results are in agreement with recent reports of the anatomical and biochemical effects of intracerebral kainic acid injections and suggest that the observed effect on feeding behavior is related to the destruction of neurons in the lateral hypothalamus.
189 citations
TL;DR: The inability to regulate water intake in the absence of food, one of the characteristic and long lasting effects of the LH syndrome, appears to be due to destruction of the NSB and the consequent decline in telencephalic content of catecholamines.
144 citations
TL;DR: The results are interpreted as suggesting that the lateral hypothalamic area and ascending dopamine neurones are components of a single system involved in the regulation of food and water intake.
127 citations
TL;DR: The similarity of the effects of aphagia, adipsia, finickiness, and food spillage to the lateral hypothalamic syndrome and the location of trigeminal structures within the diencephalon suggest that some components of the lateralothalamic syndrome are due to incidental damage to trigEMinal fibers of passage.
Abstract: Extrahypothalamic lesions of central trigeminal structures produce a syndrome of aphagia, adipsia, finickiness, and food spillage. The similarity of these effects to the lateral hypothalamic syndrome and the location of trigeminal structures within the diencephalon suggest that some components of the lateral hypothalamic syndrome are due to incidental damage to trigeminal fibers of passage.
101 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2022 | 1 |
| 2021 | 4 |
| 2020 | 4 |
| 2019 | 3 |
| 2018 | 1 |
| 2017 | 3 |