Topic
Ackee
About: Ackee is a research topic. Over the lifetime, 124 publications have been published within this topic receiving 1428 citations.
Papers published on a yearly basis
Papers
TL;DR: This work has attempted the isolation and study of the toxic constituents of the fruit in order to examine the hypothesis that these components are a contributing cause of Jamaican ‘vomiting sickness’.
Abstract: THERE is evidence in literature dating from 1887 1–3 that the fruit of Blighia sapida (known in Jamaica as ackee and in Nigeria as isin), a very common article of diet in Jamaica, may contain toxic components. Also, it has been suggested that these components are a contributing cause of Jamaican ‘vomiting sickness’, an important local disease of, as yet, undefined etiology4–6. However, this view has not been generally accepted7,8. We have attempted the isolation and study of the toxic constituents of the fruit in order to examine the hypothesis.
121 citations
TL;DR: Unripe fruit of the Jamaican ackee tree contains hypoglycin, a hypoglycaemic toxin which has caused an estimated 5000 deaths and complex effects which have implications for toxicology and the study of metabolic regulation and of many inborn errors of metabolism.
82 citations
TL;DR: Consumption of unripe ackee fruit probably caused this epidemic and may lead to a substantial number of unexplained deaths in preschool children in west Africa every year.
55 citations
TL;DR: It is suggested that the form in which hypoglycin in ackee is administered could affect the toxicological properties it exhibits, and it may be best administered within the matrix of the fruit, which is the form that humans consume it.
54 citations
TL;DR: Extracts of liver mitochondria from donor rats given hypoglycin, the toxic amino acid from the ackee plant, showed drastically reduced levels of acyl-CoA dehydrogenase activity with butyryl- CoA as substrate, consistent with quite general inhibition of fatty acid beta-oxidation by Hypoglycin.
52 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 5 |
| 2020 | 8 |
| 2019 | 5 |
| 2018 | 7 |
| 2017 | 6 |
| 2016 | 3 |