Topic
ACACB
About: ACACB is a research topic. Over the lifetime, 40 publications have been published within this topic receiving 692 citations. The topic is also known as: ACC2 & ACCB.
Papers
TL;DR: The data suggest that the pathogenic mechanism of rhabdomyolysis in lipin-1-deficient patients combines the predisposing constitutive impairment of lipid metabolism and its exacerbation by pro-inflammatory cytokines.
62 citations
TL;DR: Common polymorphisms of ACACB gene are associated with obesity and, independently, with type 2 diabetes in postmenopausal women, suggesting that the activity of acetyl-CoA carboxylase beta plays an important role in these disorders related to energy metabolism.
51 citations
TL;DR: These results in the Chinese replicate the association between T2DN and rs2268388, as seen in Japanese and European Americans, and Targeting this pathway may provide novel treatment options for the prevention of diabetic nephropathy.
Abstract: Background. A single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with susceptibility to type 2 diabetic nephropathy (T2DN) in Japanese and European-American populations. Whether this association also exists in Chinese patients is unclear. Attempts at replication in small Singaporean and Korean samples were not significant.
Methods. Eight ACACB SNPs were genotyped in 595 subjects with type 2 diabetes mellitus born in Hong Kong or southern China, 295 with advanced T2DN and 300 with long-standing diabetes lacking nephropathy. Association analyses were focused primarily on SNP rs2268388 and secondarily on flanking SNPs and haplotypes.
Results. Adjusting for age, gender and diabetes duration, ACACB SNP rs2268388 was significantly associated with advanced T2DN (odds ratio = 2.39; recessive model; P = 0.0129).
Conclusion. These results in the Chinese replicate the association between T2DN and rs2268388, as seen in Japanese and European Americans. The ACACB gene and attendant alterations in fatty acid oxidation may play important roles in susceptibility to T2DN. Targeting this pathway may provide novel treatment options for the prevention of diabetic nephropathy.
46 citations
TL;DR: This is the first study to demonstrate that RS has a powerful lipid-lowering effect in vivo, and intake of RS as a functional food may be suitable for obesity prevention and for reducing the prevalence of obesity-related diseases.
38 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2021 | 2 |
| 2020 | 2 |
| 2018 | 3 |
| 2017 | 6 |
| 2016 | 2 |
| 2015 | 4 |