Topic
1-Nitropropane
About: 1-Nitropropane is a research topic. Over the lifetime, 8 publications have been published within this topic receiving 152 citations. The topic is also known as: nitropropane & 1-NP.
Papers
TL;DR: 2-nitropropane has the potential for causing point mutations in a microbial test system, however, this compound probably will not cause a chromosome mutation of the clastogenic type.
Abstract: Three nitroparaffins (nitroethane, 1-nitropropane, and 2-nitropropane) were studied in the Salmonella typhimurium/mammalian microsome (Ames) test, with and without microsomal activation systems. Nitroethane and 2-nitropropane also were studied in an in vivo mutagenic (micronucleus) test. These studies were undertaken because these solvents are widely used in the chemical and pharmaceutical industries and 2-nitropropane was reported to cause liver cancer in rats exposed by the inhalation route. Neither nitroethane nor 1-nitropropane was active in the Ames test with Salmonella tester-strains TA1537, TA92, TA98, or TA100. However, 2-nitropropane produced a significant increase in revertants in all of these tester strains, particularly strain TA100, where 3 microliter/plate doubled the number of revertants in the presence of microsomal enzymes. Negative results were obtained with both nitroethane and 2-nitropropane in micronucleus tests. These studies have shown that 2-nitropropane has the potential for causing point mutations in a microbial test system. However, this compound probably will not cause a chromosome mutation of the clastogenic type.
43 citations
29 citations
TL;DR: Nitroethane was generally a poor substrate, but was the best inducer to produce the nitro compounds oxidizing enzyme, and formed nitrite which was found to be reduced into ammonia by the intact cells and also the crude enzyme.
Abstract: 66 representative strains of bacteria, yeasts and fungi were tested for their ability to grow in a semidefined medium containing 0.5% nitroethane as a nitrogen source. About half of them were found capable of growing in the medium. Hansenula beijerinckii, Candida utilis, and Penicillium chrysogenum were most active in assimilating nitroethane. 2-Nitropropane inhibited growth of most of the microorganisms tested in a medium containing 0.2% peptone and 0.2% glycerol. Hansenula mrakii was found to grow rapidly in the nitroethane-peptone medium after a lag phase. Nitrite was accumulated in the culture fluid after the phase of logarithmic multiplication, and increased with increase of the growth, followed by a decline after the maximum growth. The alkyl nitro compounds were oxidatively denitrified to form nitrite by the crude enzyme from Hansenula mrakii. Nitroethane was generally a poor substrate, but was the best inducer to produce the nitro compounds oxidizing enzyme. 2-Nitro-propane and nitroethane were enzymatically oxidized to nitrite, and acetone and acetaldehyde, respectively, which were isolated as 2,4-dinitrophenylhydrazones and identified. Nitrite formed was found to be reduced into ammonia by the intact cells and also the crude enzyme.
27 citations
TL;DR: In this paper, a fragmentation pattern for 1-nitropropane by comparing its mass spectrum with that of its α-, β- and γ-deuterated analogues was suggested.
Abstract: A fragmentation pattern is suggested for 1-nitropropane by comparing its mass spectrum with that of its α-, β- and γ-deuterated analogues.
27 citations
TL;DR: In this article, the Gibbs free energies of mixtures of cyclohexane + nitromethane, + nitro-alkane, plus 1-nitropropane, and + 2-nitrogenpropane at 318.15 K have been determined using a stepwise-dilution static vapour-pressure apparatus.
24 citations
Related Topics (5)
Performance Metrics
| Year | Papers |
|---|---|
| 2015 | 1 |
| 1992 | 1 |
| 1988 | 1 |
| 1979 | 2 |
| 1975 | 1 |
| 1965 | 1 |