Format your manuscript to the Molecular Systems Biology requirements — abstract, EMBO Press numbered references, and required declarations — and submit through the EMBO Press submission system without a formatting rejection.
4.6
Authored by Sumalatha Gangadhar | Published on 19 August, 2026
Getting past the desk at Molecular Systems Biology is usually less about the research and more about matching the journal’s exact submission rules. This template is built around MSB’s actual requirements — its abstract rules, EMBO Press numbered references, and the required declarations — so your submission clears screening on the first pass. Everything below tracks the MSB author guidelines; check it directly if anything looks out of date by the time you submit.
It’s a manuscript shell set up to MSB’s specifications for systems-level analysis of biological networks and quantitative biology. Molecular Systems Biology is published by EMBO Press. The shell covers the title page, the abstract, a body in Introduction, Methods, Results, and Discussion (IMRaD) order, and a reference list in EMBO Press numbered style.
Start with the title page (authors, affiliations, and ORCID iDs). The abstract is a short unstructured abstract (synopsis) for a broad readership. The body follows Introduction, Methods, Results, and Discussion (IMRaD), and the reference list uses EMBO Press numbered. Close with the declarations block: ethics approval, conflict of interest, funding, and data availability.
The details that trip up most first submissions: an abstract outside the stated word limit, references not in the journal's required format, and missing declarations (ethics, competing interests, funding). Beyond that, match your article type’s specific limits rather than assuming the defaults apply, keep EMBO Press numbered formatting consistent from the first draft, and submit only through the EMBO Press submission system — email submissions aren’t processed.
The shell mirrors what MSB’s editorial staff check first: abstract format and length, EMBO Press numbered reference formatting, and a complete declarations block. For the journal’s full aims and scope, see the MSB journal home page. Molecular Systems Biology is open access; check the current article-processing charge before you submit. Manuscripts go in through the EMBO Press submission system, which also tracks your paper through peer review.
| Element | MSB requirement |
|---|---|
| Abstract | a short unstructured abstract (synopsis) for a broad readership |
| Main text | Introduction, Methods, Results, and Discussion (IMRaD) |
| Declarations | Ethics approval, conflict of interest, funding, and data availability |
| Figures / tables | Captioned, cited in order; check format and resolution rules in the guide |
| Supplemental | Large datasets, extra tables, code — uploaded separately and cited in text |
| Submission | the EMBO Press submission system |
Read the MSB author guidelines once before drafting and once before upload. Draft the abstract after your results are stable so it matches the paper. Set EMBO Press numbered as your reference style before adding a single citation — retrofitting it later is where errors creep in.
Skim two or three recent MSB papers to calibrate depth, structure, and figure style. State your contribution in the first two paragraphs, not on page ten. Write a data-availability statement that names a real repository rather than a placeholder, and disclose any preprint or conference version with identifiers in your cover letter. Confirm current open-access pricing and any institutional agreement before committing to a fee.
Do one focused pass against the MSB author guidelines: scope fit, abstract format, length, EMBO Press numbered references, required declarations, and figure quality. Re-check the items that most often cause a bounce here — an abstract outside the stated word limit, references not in the journal's required format, and missing declarations (ethics, competing interests, funding). Then submit through the EMBO Press submission system.