Journal Article10.1046/J.1365-2516.2001.00107.X
Yttrium‐90 synoviorthesis for chronic haemophilic synovitis: Madrid experience
E. C. Rodriguez-Merchan,Víctor Jiménez-Yuste,A. Villar,Manuel Quintana,C. Lopez-Cabarcos,Fernando Hernandez-Navarro +5 more
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TL;DR: 90Y synoviorthesis should be performed in very young patients, when the amount of synovium is still moderate, and in those with a moderate degree ofsynovitis, regardless of their HIV status and the presence of inhibitor.
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Abstract: Between 1994 and 1999 we performed 66 Yttrium-90 (90Y) synoviortheses on 44 persons with haemophilia (45 knees, 12 elbows, nine ankles). At the time of injection 23 patients were HIV+ and two had inhibitors. The average age was 21.1 years (range: 9-39). Five mCi of 90Y were injected into the knees, and 3 mCi into the elbows and ankles. The average follow-up was 3.5 years (range: 1-6). Of the 45 knees, there were eight excellent, 10 good, 15 fair and 12 poor results. Of the 12 elbows there were three excellent results, five good, three fair and two poor. Of the nine ankles there were no excellent results, four good, three fair and two poor. The elbows had better results than the knees and ankles. The best results were obtained in the youngest patients, and in those with a moderate degree of synovitis, regardless of their HIV status and the presence of inhibitor. 90Y synoviorthesis should be performed in very young patients, when the amount of synovium is still moderate. Once the degree of synovitis has become severe, the expected results of radioactive synoviorthesis are worse.
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Citations
Radiosynovectomy in haemophilia: Long-term results of 500 procedures performed in a 38-year period
TL;DR: Radiosynovectomy (RS) is an effective, safe, minimally invasive, well tolerated procedure in the long-term for the treatment of chronic haemophilic synovitis and is very easy to perform.
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Radiosynovectomy in hemophilia: quantification of its effectiveness through the assessment of 10 articular parameters
TL;DR: The number of episodes of hemarthrosis and the severity of pain were the variables associated with the greatest improvement, with a 70% decrease in the amount of bleeding and in the level of pain experienced by the patient.
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•Journal Article
Radiation synovectomy with (90)Yttrium, (186)Rhenium and (169)Erbium: a systematic literature review with meta-analyses.
F. M. van der Zant,R. O. Boer,J. D. Moolenburgh,Z. N. Jahangier,J. W. J. Bijlsma,J. W. G. Jacobs +5 more
TL;DR: Reported success rates of RSO are high, but differences in effect with GC injection are less evident, although there is marked heterogeneity in study design of the (small number of) comparative studies.
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Long-term evaluation of radioisotope synovectomy with Yttrium 90 for chronic synovitis in Turkish haemophiliacs: Izmir experience.
Kaan Kavakli,Sema Aydogdu,Serdar Bedii Omay,Duman Y,Memduh Taner,Kazim Çapaci,A. Memis,Can Balkan,Deniz Yilmaz Karapinar +8 more
TL;DR: RS seems to be a safe and effective treatment for chronic synovitis causing recurrent joint bleedings in children and young adults with severe haemophilia A and B and in inhibitor patients, the best results were obtained in elbows than knees and ankles.
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The role of physical medicine and rehabilitation in haemophiliac patients.
TL;DR: Under ideal haemostatic control conditions (primary prophylaxis), people with haemophilia could achieve good physical condition which will allow them to enjoy both physical activity and a daily life without limitations.
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References
Radioactive synovectomy in haemophilic haemarthrosis. Follow-up of fifty cases.
TL;DR: Radioactive synovectomy using gold (Au 198) and rheniun (Re 186) was performed in 50 joints of 43 haemophilic patients for recurrent haemathroses and 88 percent of joints improved with this treatment.
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Chronic Haemophilic Synovitis
E. C. Rodriguez-Merchan,Nicholas J. Goddard,Christine A. Lee +2 more
- 17 Mar 2008
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Synoviorthesis with radioactive gold in haemophilia.
TL;DR: According to the experiences of the Malmö Haemophilia Centre, the best way to avoid recurrent joint bleedings and synovitis in haemophilic patients and to prevent progressive joint disease is prophylactic factor treatment.
17
Methods to treat chronic haemophilic synovitis.
TL;DR: Radioactive synoviorthesis is a relatively simple, virtually painless and inexpensive technique for the treatment of chronic haemophilic synovitis, even in patients with inhibitors, and is the best choice for patients with persistentsynovitis.