Vitamin D and multiple sclerosis: Potential pathophysiological role and clinical implications
17
TL;DR: Hypovitaminosis D is one of the environmental risk factors for MS based on numerous physiological, experimental and epidemiologic data, which can be corrected to provide an effective therapeutic option for this debilitating disease.
read more
Abstract: Multiple sclerosis (MS) is thought to arise due to an interplay of genetic and environmental risk factors. Vitamin D, besides maintaining bone health and calcium metabolism, is thought to play an immunomodulatory role in the central nervous system. Studies have shown that patients with the highest level of Vitamin D (99-152 nmol/l) had a significantly lower risk of MS than the subgroup with the lowest levels (15-63 nmol/l). Furthermore, populations having a high oral intake of vitamin D had a decreased risk of MS. Hypovitaminosis D is one of the environmental risk factors for MS based on numerous physiological, experimental and epidemiologic data, which can be corrected to provide an effective therapeutic option for this debilitating disease.
read more
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
A Review of Various Antioxidant Compounds and their Potential Utility as Complementary Therapy in Multiple Sclerosis
TL;DR: The roles of oxidative stress and non-pharmacological anti-oxidative therapies in MS are examined to establish new aims for novel treatment and provide possible benefits to MS patients.
83
Ability of vitamin D to reduce inflammation in adults without acute illness.
TL;DR: Examination of recent evidence that vitamin D status influences the level of inflammation in adults without acute illness or injury finds associations between 25-hydroxyvitamin D and inflammation markers are significant and inverse in study populations with low 25OHD levels.
37
New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease.
TL;DR: A detailed review of the linkage and potential interchangeable medication between IBD and MS in addition to Natalizumab, Trichuris suis egg therapy and vitamin D is provided.
36
Association of Multiple Sclerosis Prevalence With Sociodemographic, Health Systems, and Lifestyle Factors on a National and Regional Level
TL;DR: In this article , the authors investigated associations between MS prevalence and other factors driving regional differences, with a focus on sociodemographic, health systems, and lifestyle factors on a national and regional level.
9
Phospholipase D1 expression analysis in relapsing-remitting multiple sclerosis patients
Mohammad Mahdi Eftekharian,Tahereh Azimi,Soudeh Ghafouri-Fard,Arezou Sayad,Mir Davood Omrani,Shaghayegh Sarrafzadeh,Roghayeh Abbasalipourkabir,Mehrdokht Mazdeh,Mohammad Taheri +8 more
TL;DR: PLD1 transcripts in blood and its plasma concentrations can be used as putative biomarkers for evaluation of therapeutic responses to IFN-β in RRMS patients, but this result should be validated in future studies.
9
References
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease
TL;DR: Maintaining blood concentrations of 25-hydroxyvitamin D above 80 nmol/L (approximately 30 ng/mL) not only is important for maximizing intestinal calcium absorption but also may be important for providing the extrarenal 1alpha-hydroxylase that is present in most tissues to produce 1,25-dihydroxyv vitamin D3.
3K
Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
TL;DR: The results of this study suggest that high circulating levels of vitamin D are associated with a lower risk of multiple sclerosis.
Vitamin D physiology.
TL;DR: In conclusion, the active metabolite 1,25(OH)2D has pleiotropic effects through the vitamin D receptor and vitamin D responsive elements of many genes and on the other side rapid non-genomic effects through a membrane receptor and second messengers.
1.2K
Vitamin D intake and incidence of multiple sclerosis
Karl Münger,Shumin M. Zhang,Éilis J. O'Reilly,Miguel A. Hernán,Michael J. Olek,Walter C. Willett,Alberto Ascherio +6 more
TL;DR: A protective effect of vitamin D intake on risk of developing MS is found in two large cohorts of women following diet assessed at baseline and updated every 4 years thereafter.
1.1K