Journal Article10.1001/ARCHPEDI.1981.02130320064021
Viral Infections in Pediatric Burn Patients
TL;DR: In all of the most severely burned children CMV infections developed, and both primary and reactivation infections were observed, showing that some of these may be due to CMV infection.
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Abstract: • Bacterial and fungal infections are frequent complications of burns, but the frequency of viral infections has not been defined. In a retrospective survey of serum for viral antibodies in pediatric burn patients, 22% had fourfold increases in antibodies to cytomegalovirus (CMV); 8% had increases to herpes simplex virus and to Epstein-Barr virus; and 5% had increases to varicella-zoster virus. None of the patients had evidence of adenovirus or hepatitis B virus infection. On the basis of these observations, a prospective study of viral infections, using both serologic and viral culture techniques, was performed. This study showed that in 33% of the children CMV infection developed; in 25%, herpes simplex infection; and in 17%, adenovirus infection. In all of the most severely burned children CMV infections developed, and both primary and reactivation infections were observed. Unexplained fevers are common in pediatric burn patients, and this study shows that some of these may be due to CMV infection. (Am J Dis Child1981;135:750-753)
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Citations
The Epidemiology of Burn Wound Infections: Then and Now
TL;DR: There are few data on the epidemiology of burn wound infections from the era of early excision and closure and additional studies are needed on the indications for topical and antimicrobial prophylaxis and selective decontamination of the digestive tract.
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Epidemiology of cytomegaloviral infections: recommendations for prevention and control.
TL;DR: Good personal hygiene, especially hand washing, is the most effective means of preventing the acquisition of CMV by pregnant women and by individuals who care for children and immunocompromised patients.
143
Sepsis in pediatric burn patients.
TL;DR: Sepsis is common in the pediatric burn patient and can markedly increase morbidity and mortality, so anticipation, prompt diagnosis of infection, and effective therapy can result in successful outcomes for many of these children.
102
Suppression of natural killer-cell function in humans following thermal and traumatic injury
Beverly A. Blazar,Mary L. Rodrick,J B O'Mahony,J J Wood,Palmer Q. Bessey,Douglas W. Wilmore,John A. Mannick +6 more
TL;DR: NK-cell function was studied following the infusion of cortisol, epinephrine, and glucagon into volunteer subjects in amounts known to reproduce serum levels seen following injury of moderate severity, suggesting that the inhibition of NK- cell function seen in patients may be mediated by the stress response to injury.
92
References
Adenovirus infection in the immunocompromised patient
TL;DR: Adenovirus infection should be considered in the etiology of severe overwhelming illness in the immunocompromised host.
185
Herpesvirus infection in burned patients.
TL;DR: Herpesvirus hominis infection of healing partial-thickness burns occurred in six patients and two of these died with disseminated herpetic infection, and the possibility of a reactivated infection that resulted in extensive disease due to a post-traumatic immunologic defect is not excluded.
184
Herpetic infection of the middle and lower respiratory tract.
Gerald Nash,F. D. Foley +1 more
TL;DR: Fifteen cases of herpetic infection of the middle and lower respiratory tract are presented and discussed and bacterial and fungal superinfection represented potentially life-threatening sequelae.
121
Necrotizing tracheobronchitis and bronchopneumonia consistent with herpetic infection.
TL;DR: It appears that herpetic infection of the lower respiratory tract, unassociated with disseminated herpes, is much more common than hitherto believed.
106