Very rapid clearance after a joint bleed in the canine knee cannot prevent adverse effects on cartilage and synovial tissue.
N.W. Jansen,Goris Roosendaal,M. J. G. Wenting,Jwj Bijlsma,Matthias Theobald,Herman A.W. Hazewinkel,F.P.J.G. Lafeber +6 more
TL;DR: Blood is cleared very rapidly from the canine knee joint, but already has adverse effects on both cartilage and synovial tissue within that short time span, which can play a role in the discrepancy between long-term in vitro and in vivo effects of blood-induced joint damage.
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About: This article is published in Osteoarthritis and Cartilage. The article was published on 01 Apr 2009. and is currently open access. The article focuses on the topics: Knee Joint & Cartilage.
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Haemophilic arthropathy: the importance of the earliest haemarthroses and consequences for treatment.
TL;DR: It can be argued that prophylaxis may be stopped in adulthood, in a certain proportion of all adult patients, with acceptable consequences for orthopaedic outcome in the long term, by doing so, limited amounts of clotting factor can be used for young patients with optimal cost effectiveness.
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Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study.
L. F. D. van Vulpen,M.E. van Meegeren,G. Roosendaal,N.W. Jansen,J.M. van Laar,Roger E. G. Schutgens,S.C. Mastbergen,F.P.J.G. Lafeber +7 more
TL;DR: It is demonstrated that biochemical markers of joint tissue damage increase shortly after a single joint bleed, both in humans with established hemophilic arthropathy and in an animal model of joint damage upon a first joint bleed.
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The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia
Lize F D van Vulpen,Goris Roosendaal,B. Sweder van Asbeck,Simon C. Mastbergen,Floris P J G Lafeber,Roger E. G. Schutgens +5 more
TL;DR: Comparisons between haemochromatosis and haemophilia with respect to their clinical and histological characteristics and the role of iron as a specific target in treating these types of arthropathy are performed.
56
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Iron deposits and catabolic properties of synovial tissue from patients with haemophilia
G. Roosendaal,M. E. Vianen,M. J. G. Wenting,A. C. van Rinsum,H. M. Van Den Berg,F.P.J.G. Lafeber,J. W. J. Bijlsma +6 more
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TL;DR: In vivo exposure of articular cartilage to blood for a relatively short time results in lasting changes in chondrocyte activity and in cartilage matrix integrity, changes that may predict lasting joint damage over time.
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