Journal Article10.1111/J.1365-2222.1990.TB02795.X
Venous blood platelets decrease during allergen-induced asthmatic reactions.
Piero Maestrelli,Piera Boschetto,E. Zocca,S. Crescioli,P. Baroldi,Cristina E. Mapp,Leonardo M. Fabbri +6 more
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TL;DR: Results suggest that platelets may be involved in the pathogenesis of allergen‐induced asthmatic reactions, and are associated with bronchoconstriction induced by methacholine.
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Abstract: Summary
To determine whether circulating platelets alter during asthmatic reactions induced by allergens, we studied nine subjects previously shown to develop an early or dual asthmatic reaction after inhalation challenge with extracts of house dust mite or grass pollen. In each subject, FEV1, circulating platelets and leucocytes were measured before, 15, 30 and 60 min, and 2, 4, 6 and 8 hr after inhalation of allergen and diluent control administered in a single-blind, randomized fashion. The same procedure was repeated in six of the nine subjects after bronchoconstriction induced by methacholine. Each subject developed an early asthmatic reaction after allergen inhalation challenge, which was followed by a late asthmatic reaction in six subjects and by an equivocal late asthmatic reaction in two of them (fall in FEV1 of 15 and 17% respectively). Compared with the control day, circulating platelets significantly decreased during the allergen-induced early asthmatic reaction (P < 0·025, at 30 min). Platelet counts returned to baseline values within 4 hr and remained steady thereafter both in subjects who did and did not develop a late asthmatic reaction. No changes in platelet counts occurred after bronchoconstriction induced by methacholine. Diurnal increase of leucocyte numbers occurred after challenge with both allergen and diluent control. These results suggest that platelets may be involved in the pathogenesis of allergen-induced asthmatic reactions.
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Platelet Dynamics following Allergen Challenge in Allergic Asthmatics
TL;DR: The results suggest that persistent thrombocytopaenia accompanies allergen exposure and persists beyond changes in airway obstruction at a time when airway inflammation is present, providing further evidence that platelets may be involved in allergic disease.
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Platelet-Eosinophil Interactions As a Potential Therapeutic Target in Allergic Inflammation and Asthma.
TL;DR: Non-thrombotic platelet activation in the context of allergy and the association of platelets with eosinophils is explored, to reveal how these phenomena may lead to the discovery of novel therapeutic targets.
Delayed generation of thrombin in clotting blood of atopic patients with hayfever and asthma.
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References
Activation of blood coagulation during inhalation challenge tests.
TL;DR: A relationship between activation of blood coagulation factors and the type of asthmatic response elicited after challenge test is suggested and a positive correlation, although weak, was found between the time for maximum shortening of recalcification time and the time of onset of the late reaction.
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Platelet activation in allergic asthma.
TL;DR: The failure to demonstrate any evidence of platelet activation on measurement of P-thromboglobulin, or in platelet aggregations, following challenge with histamine or antigen, is supported by the aggrega tion results, and by the failure to demonstrating any change in thromboxane B2 which normally rises with plateletactivation.
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Platelet activation during antigen-induced airway reactions in asthmatic subjects.
TL;DR: Chemical mediators derived from basophils or mast cells are considered to have an important role in the pathophysiology of asthma, however, studies designed to document this relation have provided inconsistent results.
The platelet in asthma
TL;DR: Hypothese: l'exacerbation des symptomes d'asthme (apres inhalation d'allergene) serait due a une production dans le poumon de facteur activant les plaquettes («paf-acether»).