Journal Article10.1111/J.1365-2222.1990.TB02795.X
Venous blood platelets decrease during allergen-induced asthmatic reactions.
Piero Maestrelli,Piera Boschetto,E. Zocca,S. Crescioli,P. Baroldi,Cristina E. Mapp,Leonardo M. Fabbri +6 more
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TL;DR: Results suggest that platelets may be involved in the pathogenesis of allergen‐induced asthmatic reactions, and are associated with bronchoconstriction induced by methacholine.
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Abstract: Summary
To determine whether circulating platelets alter during asthmatic reactions induced by allergens, we studied nine subjects previously shown to develop an early or dual asthmatic reaction after inhalation challenge with extracts of house dust mite or grass pollen. In each subject, FEV1, circulating platelets and leucocytes were measured before, 15, 30 and 60 min, and 2, 4, 6 and 8 hr after inhalation of allergen and diluent control administered in a single-blind, randomized fashion. The same procedure was repeated in six of the nine subjects after bronchoconstriction induced by methacholine. Each subject developed an early asthmatic reaction after allergen inhalation challenge, which was followed by a late asthmatic reaction in six subjects and by an equivocal late asthmatic reaction in two of them (fall in FEV1 of 15 and 17% respectively). Compared with the control day, circulating platelets significantly decreased during the allergen-induced early asthmatic reaction (P < 0·025, at 30 min). Platelet counts returned to baseline values within 4 hr and remained steady thereafter both in subjects who did and did not develop a late asthmatic reaction. No changes in platelet counts occurred after bronchoconstriction induced by methacholine. Diurnal increase of leucocyte numbers occurred after challenge with both allergen and diluent control. These results suggest that platelets may be involved in the pathogenesis of allergen-induced asthmatic reactions.
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Clive P. Page,Simon C. Pitchford +1 more
TL;DR: Despite significant platelet activation in patients with allergic diseases, it is of note that these patients have been described as having a mild haemostastic defect, rather than an increased incidence of thrombosis, which suggests a dichotomy exists in platelets activation during inflammation compared to haemOSTasis.
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Platelet Dynamics following Allergen Challenge in Allergic Asthmatics
TL;DR: The results suggest that persistent thrombocytopaenia accompanies allergen exposure and persists beyond changes in airway obstruction at a time when airway inflammation is present, providing further evidence that platelets may be involved in allergic disease.
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Platelet-Eosinophil Interactions As a Potential Therapeutic Target in Allergic Inflammation and Asthma.
TL;DR: Non-thrombotic platelet activation in the context of allergy and the association of platelets with eosinophils is explored, to reveal how these phenomena may lead to the discovery of novel therapeutic targets.
Delayed generation of thrombin in clotting blood of atopic patients with hayfever and asthma.
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•Journal Article
IgE induced blood coagulation alterations in the rabbit: consumption of coagulation factors XII, XI, and IX in vivo
TL;DR: It is proposed that specific IgE antibody can induce directly or indirectly the activation of intrinsic blood coagulation in vivo.
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Pulmonary platelet kinetics in asthma.
TL;DR: Platelets produce a range of bronchoconstrictor mediators, and the existence of an intrapulmonary platelet pool in normal subjects is argued against; transpulmonary transit time was slightly prolonged in one asthmatic subject; andAntigen induced bronchconstriction was therefore not accompanied by intrapu pulmonary platelet accumulation.
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