Journal Article10.1111/J.1365-2222.1990.TB02795.X
Venous blood platelets decrease during allergen-induced asthmatic reactions.
Piero Maestrelli,Piera Boschetto,E. Zocca,S. Crescioli,P. Baroldi,Cristina E. Mapp,Leonardo M. Fabbri +6 more
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TL;DR: Results suggest that platelets may be involved in the pathogenesis of allergen‐induced asthmatic reactions, and are associated with bronchoconstriction induced by methacholine.
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Abstract: Summary
To determine whether circulating platelets alter during asthmatic reactions induced by allergens, we studied nine subjects previously shown to develop an early or dual asthmatic reaction after inhalation challenge with extracts of house dust mite or grass pollen. In each subject, FEV1, circulating platelets and leucocytes were measured before, 15, 30 and 60 min, and 2, 4, 6 and 8 hr after inhalation of allergen and diluent control administered in a single-blind, randomized fashion. The same procedure was repeated in six of the nine subjects after bronchoconstriction induced by methacholine. Each subject developed an early asthmatic reaction after allergen inhalation challenge, which was followed by a late asthmatic reaction in six subjects and by an equivocal late asthmatic reaction in two of them (fall in FEV1 of 15 and 17% respectively). Compared with the control day, circulating platelets significantly decreased during the allergen-induced early asthmatic reaction (P < 0·025, at 30 min). Platelet counts returned to baseline values within 4 hr and remained steady thereafter both in subjects who did and did not develop a late asthmatic reaction. No changes in platelet counts occurred after bronchoconstriction induced by methacholine. Diurnal increase of leucocyte numbers occurred after challenge with both allergen and diluent control. These results suggest that platelets may be involved in the pathogenesis of allergen-induced asthmatic reactions.
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References
Standardization of bronchial inhalation challenge procedures
Hyman Chai,Richard S. Farr,Luz A. Froehlich,David A. Mathison,James A. McLean,Richard R. Rosenthal,Albert L. Sheffer,Sheldon L. Spector,Robert G. Townley +8 more
TL;DR: Criteria for procedures and materials used were suggested in order to standardize bronchial inhalation challenges as they pertain to allergic disease.
1.5K
Mediators of immediate hypersensitivity reactions.
Serafin We,Austen Kf +1 more
TL;DR: Many of the signs and symptoms of allergic responses in humans can now be attributed to specific mast-cell responses, thanks to considerable progress in elucidating the structure and function of these mediators.
263
The receptor for IgE on blood platelets.
Michel Joseph,André Capron,Ameisen Jc,Monique Capron,Han Vorng,Véronique Pancré,J P Kusnierz,Claude Auriault +7 more
TL;DR: Observations place emphasis on the potential role of the platelets in immediate‐type allergic reactions by their direct interaction with IgE antibody molecules, through a specific receptor.
178
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The Late Phase Skin Reaction: Evidence for Activation of the Coagulation System in an IgE-Dependent Reaction in Man
TL;DR: The failure of RW-H injection to induce LPR argues against a gatekeeper role for WFR in the genesis of LPR and suggests that LPR may follow small RW doses, suggesting activation of the coagulation system in these IgE-dependent “delayed in time” reactions.
139
The Role of Platelets in the Adult Respiratory Distress Syndrome Culprits or Bystanders
TL;DR: Lors du syndrome de detresse respiratoire de l'adulte, stimulation de l'sagregation plaquettaire ce qui libere des substances vasoconstrictives qui contribuent a l'hypertension pulmonaire et a la bronchoconstriction ce qui altere les relations ventilation-perfusion pulmonaires
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