Vaccine development against coronavirus (2003 to present): An overview, recent advances, current scenario, opportunities and challenges.
43
Chat with Paper
AI Agents for this Paper
Find similar papers on Google Scholar, PubMed and Arxiv
Write a critical review of this paper
Analyze citations of this paper to find unaddressed research gaps
Citations
Tweet Topics and Sentiments Relating to COVID-19 Vaccination Among Australian Twitter Users: Machine Learning Analysis.
TL;DR: The authors used machine learning methods to extract topics and sentiments relating to COVID-19 vaccination on Twitter and found that nearly two-thirds of the sentiments of all tweets expressed a positive public opinion about the COVID19 vaccine; around one-third were negative.
Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies
Miquéias Lopes-Pacheco,Pedro L. Silva,Fernanda F. Cruz,Denise Battaglini,Chiara Robba,Paolo Pelosi,Marcelo M. Morales,Celso Caruso Neves,Patricia R. M. Rocco +8 more
TL;DR: In this paper, the authors summarize the major features of SARS-CoV-2 biology and the current understanding of COVID-19 pathogenesis, as well as its clinical repercussions in the lung, heart, kidney, bowel, liver, and brain.
A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2.
Ankit Gupta,Anjali Anand,Neha Jain,Sandeep Goswami,Anbalagan Ananthraj,Sharanabasava Patil,R. Singh,Amit Kumar,Tripti Shrivastava,Shinjini Bhatnagar,Guruprasad R. Medigeshi,Tarun Kumar Sharma +11 more
TL;DR: In this paper, a 44-mer G-quadruplex-forming DNA aptamer against spike trimer antigen of SARS-CoV-2 was identified, which can detect as low as 2nM of antigen.
62
Design of a novel multiple epitope-based vaccine: An immunoinformatics approach to combat SARS-CoV-2 strains.
Muhammad Naveed,Sana Tehreem,Sundas Arshad,Syeda Aniqa Bukhari,Muhammad Aqib Shabbir,Ramsha Essa,Nouman Ali,Sumera Zaib,Ajmal Khan,Ahmed Al-Harrasi,Imtiaz Khan +10 more
TL;DR: In this paper, a potential vaccine was developed by targeting B and T-cell epitopes using bioinformatics approaches, and the constructed vaccine showed good results of worldwide population coverage and promising immune response, and these in silico findings would be a breakthrough in the development of an effective vaccine to eradicate SARS-CoV-2 globally.
48
Current advances and challenges in COVID-19 vaccine development: from conventional vaccines to next-generation vaccine platforms
Ameneh Jafari,Fahima Danesh-Pouya,Zahra Niknam,Meghdad Abdollahpour-Alitappeh,Mostafa Rezaei-Tavirani,Yousef Rasmi +5 more
TL;DR: In this article , a review outlines key strategies for generating SARS-CoV-2 vaccine candidates, along with the mechanism of action, advantages, and potential limitations of each vaccine.
42
References
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
12.5K
Structure, Function, and Evolution of Coronavirus Spike Proteins.
TL;DR: This article reviews current knowledge about the structures and functions of coronavirus spike proteins, illustrating how the two S1 domains recognize different receptors and how the spike proteins are regulated to undergo conformational transitions.
2.7K
Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals.
Ling Ni,Fang Ye,Meng Li Cheng,Yu Feng,Yong Qiang Deng,Hui Zhao,Peng Wei,Jiwan Ge,Mengting Gou,Xiaoli Li,Lin Sun,Tian-Shu Cao,Pengzhi Wang,Chao Zhou,Rong-Rong Zhang,Peng Liang,Han Guo,Xinquan Wang,Cheng-Feng Qin,Fang Chen,Chen Dong +20 more
TL;DR: Blood from COVID-19 patients who have recently become virus-free and therefore were discharged was collected, and SARS-CoV-2-specific humoral and cellular immunity in 8 newly discharged patients was detected, and there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells.
1.1K
Coronavirus disease 2019 (COVID-19): current status and future perspectives.
TL;DR: Intensive research on the newly emerged SARS-CoV-2 is urgently needed to elucidate the pathogenic mechanisms and epidemiological characteristics and to identify potential drug targets, which will contribute to the development of effective prevention and treatment strategies.
1.1K
Hosts and Sources of Endemic Human Coronaviruses.
TL;DR: New data suggest that HCoV-229E may actually be transferred from dromedary camels similar to Middle East respiratory syndrome (MERS) coronavirus, which provides important ecological parallels to the present prepandemic pattern of host associations of the MERS coronav virus.
1K